Yingtian Sun

Keywords charge blocks nuclear speckles phase separation SRRM2 phosphorylation interfacial tension elastic bending rigidity coarsening CK2 alternative splicing Get full text access Log in, subscribe or purchase for full access. References 1. Lyon, A.S. ∙ Peeples, W.B. ∙ Rosen, M.K. A framework for understanding the functions of biomolecular condensates across scales Nat. Rev. Mol. Cell Biol. 2021; 22:215-235 2. Shin, Y. ∙ Brangwynne, C.P. Liquid phase condensation in cell physiology and disease Science.

Highlights • SRRM2 and SON form co-existing dense phases within nuclear speckles • SRRM2 undergoes phase separation to drive NS subcompartmentalization • SRRM2 RS domains form high-order oligomers to trigger NS condensation Summary Nuclear speckles (NSs) are nuclear biomolecular condensates that are postulated to form by macromolecular phase separation, although the detailed underlying forces driving NS formation remain elusive.