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Yingxue Ma

As seen in: MDPI, ACS Publications
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Articles

Analysis of the Relationship Between the Charge Increment of the SARS-CoV-2 Spike Protein and Evolution

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By Yingxue Ma, Ying Zhang, Menghao Chen, Kun Wang
| Preprints.org
Submitted: 18 September 2025 Posted: 19 September 2025 You are already at the latest version The changes in charge distribution caused by mutations in the spike protein may play a crucial role in balancing infectivity and immune evasion during the evolution of SARS-CoV-2.
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A Designed Analog of an Antimicrobial Peptide, Crabrolin, Exhibits Enhanced Anti-Proliferative and In Vivo Antimicrobial Activity

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By Yingxue Ma, Ruize Sun, Aifang Yao, Wanchen Zou
| MDPI
1. Introduction ESKAPE pathogens (Enterococcus faecium (E. faecium), Staphylococcus aureus (S. aureus), Klebsiella pneumoniae (K. pneumoniae), Acinetobacter baumannii, Pseudomonas aeruginosa (P. aeruginosa), and Enterobacter species), which include six nosocomial pathogens, have caused a highly complex and concerning situation for human beings due to their growing multi-drug resistance and virulence [1].
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Nucleobase Clustering Contributes to the Formation and Hollowing of Repeat-Expansion RNA Condensate

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By Yingxue Ma, Haozheng Li, Zhou Gong, Shuai Yang
| ACS Publications
RNA molecules with repeat expansion sequences can phase separate into gel-like condensate, which could lead to neurodegenerative diseases. Here, we report that, in the presence of Mg2+, RNA molecules containing 20× CAG repeats self-assemble into three morphologically distinct droplets. Using hyperspectral stimulated Raman microscopy, we show that RNA phase separation is accompanied by the clustering of nucleobases while forfeiting the canonical base-paired structure.
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