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Yingying Han on Muck Rack

Yingying Han

As seen in: Nature, Wiley Online Library, Oxford Academic, Frontiers, MDPI, Science Magazine, Cell Reports, Cell Press, Physical Review B, Dove Medical Press and
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Articles

A telomere-to-telomere genome reveals arachidonic acid as a key regulator of hepatic lipid metabolism during hibernation

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By Linjuan Wang, Pengyu Chen, Quanzheng Yun, Qikun Zhang, Xin Xing, Yue Zhou, Chuhan Wang, Qiang Weng, Yingying Han, Yuning Liu, Haolin Zhang, Zhengrong Yuan, Qingjing Gao
| Nature Verified
Abstract Elucidating the molecular mechanisms governing mammalian hibernation is crucial for understanding energy homeostasis and physiological adaptation to extreme environments. In this study, we present the first high-quality telomere-to-telomere (T2T) reference genome (2.69 Gb) of the Daurian ground squirrel (Spermophilus dauricus), a typical hibernating mammal.
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Targeting the Ip6k2–Runx2 axis disrupts osteoblast–osteoclast coupling to treat osteoporosis

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By Guixing Ma, Yong Chen, Siyuan Cheng, Fen Wang, Yingying Han, Litong Chen, Zhen Ding, Yiran Li, Huiling Cao
| Nature Verified
Abstract Excessive osteoclast activation disrupts bone homeostasis, contributing to osteoporosis (OP). While Runx2 is known to regulate osteoblast differentiation, its role in osteoclasts is less clear. Using conditional knockout models, we demonstrate that Runx2 directly drives osteoclast differentiation by regulating Ctsk transcription. However, its dual function in both osteoblasts and osteoclasts limits therapeutic potential.
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Chronic exposure to LED lighting impairs prefrontal cortex-dependent cognitive functions in adolescent rats

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By Jing L. Wang, Xiaona Wang, Yingying Han, Chong Sun, Shunqi Wang, Chaolin Ma
| Nature Verified
Abstract The Light-emitting diodes (LEDs) have already replaced conventional lighting sources due to their energy efficiency and environmental benefits. Although previous studies suggest that chronic exposure to LED may affect human physiological health, its impact on cognitive functions remains unclear. To simulate typical human lighting conditions, we established an animal model which Sprague-Dawley (SD) rats exposed to LED light daily from 18:00 to 22:00 (ZT12-ZT16) for one month.
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