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Yingying Pu on Muck Rack

Yingying Pu

As seen in: Nature, Cell Press
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Articles

SNRPD2–CPSF7–UBE2K axis drives ovarian cancer progression via alternative splicing–polyadenylation crosstalk

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By Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Yingying Pu, Ning Yang, Yuchao Diao
| Nature Verified
Abstract Aberrant alternative polyadenylation (APA) and alternative splicing (AS) contribute to numerous diseases, including cancer; however, their coordinated roles in ovarian cancer remain poorly understood. Here, we investigated CPSF7, an APA factor markedly upregulated in ovarian cancer and associated with poor prognosis.
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Spliceosomal component SNRPE drives cell proliferation by regulating CTP synthase 1 mRNA splicing in ovarian cancer

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By Yingying Pu, Zhongshao Chen, Qianqian Gao, Yanling Liu, Ning Yang, Yingwei Li, Beihua Kong
| Nature Verified
Abstract Sustained proliferation is a hallmark of tumor cells. Cancer-associated alternative splicing (AS) events can provide proliferative advantages in tumors, suggesting that identifying aberrant RNA splicing events linked to proliferation in ovarian cancer (OC) may reveal novel therapeutic targets. In this study, we found that small nuclear ribonucleoprotein polypeptide E (SNRPE) was overexpressed in OC, particularly in the proliferative subtype, and indicated worse clinical prognosis.
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SNRPD2-mediated regulation of DDX39B splicing promotes endometrial cancer progression by suppressing the activation of CTSC cryptic exons - Cell Death & Disease

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By Yingwei Li, Zhongshao Chen, Yanling Liu, Yuehan Gao, Yingying Pu, Qianqian Gao, Feng Gao, Ning Yang, Peng Li
| Nature Verified
Abstract Recent studies have reported the overexpression of Sm proteins in several cancers, suggesting their potential as therapeutic targets; however, the specific Sm family members involved in endometrial cancer and their mechanisms remain unclear. Here, we show that the Sm protein SNRPD2 is markedly upregulated in both fresh-frozen and formalin-fixed paraffin-embedded (FFPE) endometrial cancer specimens and that its overexpression correlates with poorer clinical outcomes.
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