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Yini Xiao on Muck Rack

Yini Xiao

As seen in: Science Magazine, Cell Press, The Journal of Clinical Investigation
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Articles

Synthetic organizer cells guide development via spatial and biochemical instructions

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By Toshimichi Yamada, Coralie Trentesaux, Jonathan M. Brunger, Yini Xiao, Adam Stevens, Iain Martyn, Petr Kasparek, Neha P. Shroff, Angelica Aguilar, Benoît Bruneau, Dario Boffelli, Ophir Klein, Wendell A. Lim
| Cell Press Verified
Keywords synthetic organizer signaling center synthetic biology developmental biology morphogen gradient differential adhesion synthetic cell adhesion molecules synCAMs regenerative medicine synthetic embryos gastruloid Get full text access Log in, subscribe or purchase for full access. References 1. Shahbazi, M.N. ∙ Siggia, E.D. ∙ Zernicka-Goetz, M. Self-organization of stem cells into embryos: A window on early mammalian development Science. 2019; 364:948-951 2. Trentesaux, C. ∙ Yamada, T.
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Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs

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By Milos S. Simic, Nishith Reddy, Nicholas Dulvy, Hasna Maachi, Yini Xiao, Wei Yu, Whitney Tamaki, Greg Allen, Audrey Parent, Matthias Hebrok, Wendell A. Lim, Yurie Tonai, Daniela A. Cabanillas, Ella Serrano-Wu, Philip T. Pauerstein
| Science Magazine Verified
Research Article CELL ENGINEERING Nishith R. Reddy https://orcid.org/0000-0001-5912-6925, Hasna Maachi https://orcid.org/0009-0002-3044-2582, [...] , Yini Xiao https://orcid.org/0009-0007-5108-7301, Milos S. Simic https://orcid.org/0000-0002-1167-0857, [...] , Wei Yu https://orcid.org/0000-0002-3154-5084, Yurie Tonai https://orcid.org/0000-0001-9610-6667, Daniela A. Cabanillas https://orcid.org/0000-0002-1321-9656, Ella Serrano-Wu https://orcid.org/0009-0003-1666-1778, Philip T.
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Loss of ZNF148 enhances insulin secretion in human pancreatic β cells

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By JCI Insight, Eleonora de Klerk, Christopher H. Emfinger, Yini Xiao
| The Journal of Clinical Investigation
Abstract Insulin secretion from pancreatic β cells is essential to the maintenance of glucose homeostasis. Defects in this process result in diabetes. Identifying genetic regulators that impair insulin secretion is crucial for the identification of novel therapeutic targets. Here, we show that reduction of ZNF148 in human islets, and its deletion in stem cell–derived β cells (SC–β cells), enhances insulin secretion.
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