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Post-marketing safety surveillance and signal characterization of the novel dissociative steroid Vamorolone in Duchenne muscular dystrophy: a comparative disproportionality analysis based on FAERS data
Abstract Objective: To comprehensively evaluate the real-world post-marketing safety profile of the novel dissociative steroid Vamorolone and perform a comparative analysis against the traditional glucocorticoid deflazacort. Methods: Vamorolone-associated adverse event reports were extracted from the FAERS database (2023Q4–2025Q4) without indication restrictions to maximize detection sensitivity.
A reliability evaluation method for complex systems based on the editable GSPN and adaptive Monte Carlo simulation
CONFLICT OF INTEREST STATEMENT The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. REFERENCES 1, , , , . Effective sensor placement based on a VIKOR method considering common cause failure in the presence of epistemic uncertainty. Eksploat Niezawodn—Maint Reliab. 2021; 23(2): 253-262. doi:10.17531/ein.2021.2.5 2, , , .
A reliability analysis technique for complex systems with retaining fuzzy information
This paper proposed a method for the reliability analysis of systems characterized by fuzzy failure probabilities and intricate failure behaviors, while retaining the fuzzy information throughout the analysis process. Specifically, we introduced a combinational modeling method that integrates generalized stochastic Petri nets (GSPN) and dynamic fault trees (DFT) to capture the dynamic failure behaviors and address the limitations of DFT modeling.
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