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Chenying Li

As seen in: Nature, MDPI, ACS Publications, Cell Press
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Articles

Olverembatinib plus immunotherapy versus olverembatinib plus allogeneic hematopoietic cell transplantation in adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia

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By Chenying Li, Hongyan Tong, Huafeng Wang, Yanling Ren, Jiejing Qian, Xinping Zhou, Gaixiang Xu, Liangshun You, Liping Mao, Haitao Meng, Wenjuan Yu, Xingnong Ye, Min Yang, Jian Huang, De Zhou, Wanzhuo Xie, Jie Jin, Yinjun Lou
| Nature Verified
To the Editor: Philadelphia chromosome–positive (Ph⁺) acute lymphoblastic leukemia (ALL) accounts for approximately 20–30% of adult B-cell ALL cases [1]. Historically, Ph⁺ ALL has been associated with poor outcomes due to intrinsic chemoresistance. The integration of BCR::ABL1 tyrosine kinase inhibitors (TKIs) into frontline induction regimens has dramatically improved complete remission (CR) rates to >95%.
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Krüppel-like factor 4 downregulation during esophageal cancer formation facilitates immune evasion and impairs immunotherapy

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By Xiao Hu, Chenying Li, Dongxu Li, Ying Cao, Ziyi He, Zhenghao Dong, Xiaoqi Jiang, Tao Xiang, Yonglin Yi, HanZhang Yi, Dongxin Lin, Chen Wu
| Nature Verified
Abstract Impaired antigen processing and presentation are critical for cancer immune evasion, but the underlying mechanism is not fully known. Here, we show that downregulation of Krüppel-like factor 4 (KLF4) expression during the development of cancer is essential in this immuno-decisive process. We find that suppressed KLF4 expression causes diminished MHC class I production in esophageal cancer, forming immunosuppressive niches that limit CD8⁺ T cell infiltration.
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Constructing artificial methylotrophic S. cerevisiae for chondroitin sulfate production using a multidimensional combinatorial strategy

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By Yixun Jiang, Wenjie Ma, Chenying Li, Ruirui Shi, Guangyao Tang, Yaxin He, Jiaqi Li, Zepin Guo, Yuxin Zhang, Shuhong Mao, Mingdong Yao, Zhengqiang Jiang, Fuping Lu, Hui-Min Qin
| Nature Verified
Abstract The concept of a methanol-based circular bioeconomy envisions the conversion of greenhouse gases into one-carbon compounds, which are subsequently utilized to produce high-value-added products. However, the toxicity of intermediates limits the metabolic efficiency within chassis strains.
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