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Yinmin Gu on Muck Rack

Yinmin Gu

As seen in: Nature, Cell Press, The Journal of Clinical Investigation
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Articles

P5CS represses tumor progression via inhibiting assembly of 48S pre-translation initiation complex

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By Qingqing Zhang, Shuwen Cheng, Yinmin Gu, Yongbo Pan, Xiaofeng Zhu, Jinghan Sun, Shan Gao
| Cell Press Verified
Keywords translation regulation eIF3a/3d 43/48S P5CS RNA-binding protein Get full text access Log in, subscribe or purchase for full access. References 1. Holmes, R.S. Comparative and evolutionary studies of ALDH18A1 genes and proteins Chem. Biol. Interact. 2017; 276:2-8 2. Guo, Y.F. ∙ Duan, J.J. ∙ Wang, J. ... Inhibition of the ALDH18A1-MYCN positive feedback loop attenuates MYCN-amplified neuroblastoma growth Sci. Transl. Med. 2020; 12, eaax8694 3.
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Posttranscriptional regulation of PD-1 by PRMT5/WDR77 complex shapes T cell effector function and antitumor immunity

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By Yinmin Gu, Yongbo Pan, Chang Pan, Qiang Pang
| The Journal of Clinical Investigation
Abstract The regulation of the programmed cell death protein 1 (PD-1) gene, PDCD1, has been widely explored at transcription and posttranslational levels in T cell function and tumor immune evasion. However, the mechanism for PDCD1 dysregulation at the posttranscriptional level remains largely unknown.
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PD-L2 of tumor-derived exosomes mediates the immune escape of cancer cells via the impaired T cell function - Cell Death & Disease

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By Xiaofeng Zhu, Yinmin Gu, Hongbo Hu
| Nature Verified
Abstract The function of PD-1/PD-L1 axis have been intensively studied for immune escape of various cancers. However, the underlying function of PD-L2 remains poorly understood. Here, we demonstrate that PD-L2 is majorly expressed in exosomes with surface localization by clear cell renal cell carcinoma (ccRCC) cells. Tumor cell-derived exosome PD-L2 (TDE-PD-L2) exhibits high expression compared with TDE-PD-L1 in various cancers.
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