Yinyan Ma

Cancer cells shift their metabolism to aerobic glycolysis (i.e., fermentation of glucose as energy in the presence of ample oxygen), but the underlying mechanisms remain elusive. Ou et al. identify Abhd5, an activator of intracellular fat breakdown, as a suppressor of this metabolic shift and associated malignancies in colon cancer.

Selective Inactivation of CGI-58 in BAT Induces iBAT Steatotic Hypertrophy and Hyperplasia   BAT-KO Mice Have Normal Energy Expenditure and Body Temperature at Room Temperature or Thermoneutrality   CGI-58 Deletion in BAT Does Not Reduce Whole-Body Thermogenic Capacity   WAT Lipolysis Is Essential for Thermogenesis during Fasting     Chemical Denervation of the Sympathetic Nerves in iWAT Pads Cytosolic LD lipolysis in adipocytes is often stimulated by sympathetic activation.

Sphingolipids are a diverse class of essential cellular lipids that function as structural membrane components and as signaling molecules. Cells acquire sphingolipids by both de novo biosynthesis and recycling of exogenous sphingolipids. The individual importance of these pathways for the generation of essential sphingolipids in differentiated cells is not well understood.