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Articles by Yohei Doi
Age-dependent sex differences in acute kidney injury among patients with chronic kidney disease
Abstract Patients with chronic kidney disease (CKD) are susceptible to acute kidney injury (AKI), which worsens clinical prognosis. Sex differences in AKI incidence and subsequent kidney prognosis remain uncertain in CKD. This multicenter, retrospective cohort study analyzed outpatients with non-dialyzed CKD. Using Cox regression models, AKI incidence was compared between sexes.
Genomic analysis of intrahospital transmission of carbapenem-resistant Gram-negative bacteria: a multicentre study in Japan
Article metrics loading... /content/journal/mgen/10.1099/mgen.0.001770 Metrics Download as PowerPoint /deliver/fulltext/mgen/12/7/mgen001770.html?itemId=/content/journal/mgen/10.1099/mgen.0.001770&mimeType=html&fmt=ahah References Nordmann P, Poirel L. Epidemiology and diagnostics of carbapenem resistance in gram-negative bacteria. Clin Infect Dis 2019; 69:S521–S528 [View Article] [PubMed] [Google Scholar] Tacconelli E, Cataldo MA, Dancer SJ, De Angelis G, Falcone M et al.
Carbapenem-resistant Gram-negative bacilli infections in Japanese patients with cancer
Abstract Carbapenem-resistant bacteria represent a significant challenge for patients with cancer; however, the characteristics and prognoses of carbapenem-resistant Gram-negative bacilli (CRGNB) infections in Japanese patients with cancer remain unclear. Therefore, we aimed to investigate the features and outcomes of CRGNB infections in this population.
Case Commentary: When one target is not enough—PBP3 insertions and target redundancy in Escherichia coli
Antimicrobial Chemotherapy Commentary COMMENTARY Penicillin-binding proteins (PBPs) build and maintain the bacterial cell wall, and β-lactams exert antibacterial activity by inhibiting PBPs, disrupting cell wall architecture and causing bacterial death (1).
Hooked on IDWeek with Yohei Doi, MD, PhD
Hooked on IDWeek with Yohei Doi, MD, PhD October 21, 2025 1 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . Subscribe We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com. Back to Healio ATLANTA — I was always interested in microbiology.
Hooked on IDWeek with Yohei Doi, MD, PhD
Hooked on IDWeek with Yohei Doi, MD, PhD October 21, 2025 1 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . Subscribe We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com. Back to Healio ATLANTA — I was always interested in microbiology.
Cefotaxime-Resistant Neisseria meningitidis Sequence Type 4821 Causing Fulminant Meningitis
Hasbun R. Progress and challenges in bacterial meningitis: a review. JAMA. 2022;328:2147–54. DOIPubMedGoogle Scholar Chen M, Harrison OB, Bratcher HB, Bo Z, Jolley KA, Rodrigues CMC, et al. Evolution of sequence type 4821 clonal complex hyperinvasive and quinolone-resistant meningococci. Emerg Infect Dis. 2021;27:1110–22. DOIPubMedGoogle Scholar Chen M, Shao Y, Luo J, Yuan L, Wang M, Chen M, et al.
Efficacy and Safety of 5-Day Oral Ensitrelvir for Patients With Mild to Moderate COVID-19: The SCORPIO-SR Randomized Clinical Trial
Key Points Question Can ensitrelvir, an oral SARS-CoV-2 3C-like protease inhibitor, shorten the duration of symptoms in patients with mild to moderate COVID-19 irrespective of the presence of risk factors for severe disease?
Mediators between canagliflozin and renoprotection vary depending on patient characteristics: Insights from the CREDENCE trial
Percentage mediation Of the 22 biomarkers that were eligible for mediators at 52 weeks, four biomarkers (haematocrit [47%, 95% CI: 2%-92%], RBC count [41%, 95% CI: 2%-80%], haemoglobin [40%, 95% CI: 3%-77%] and UACR [29%, 95% CI: 0%-58%]) had statistically significant results (Figure 1).
A Randomized Phase 2/3 Study of Ensitrelvir, a Novel Oral SARS-CoV-2 3C-like Protease Inhibitor, in Japanese Patients With Mild-to-Moderate COVID-19 or Asymptomatic SARS-CoV-2 Infection: Results of the Phase 2a Part
DISCUSSION This is the first clinical study to assess the antiviral efficacy and safety of a novel oral SARS-CoV-2 3CL protease inhibitor, ensitrelvir, in patients with mild-to-moderate COVID-19 or asymptomatic SARS-CoV-2 infection. This study used infectious viral titer as the primary endpoint to assess the antiviral efficacy of anti-SARS-CoV-2 agents. A majority of the enrolled patients had been vaccinated, which reflects the real-world scenario.
Treatment of Acinetobacter spp. Infections
Infections caused by carbapenem-resistant Acinetobacter spp. are considered an urgent public health problem. Antibiotic options are scarce but new drugs may be available in the near future. We discuss this important topic with experts in the field. Topics discussed: Acinetobacter as an opportunistic pathogen Therapeutic approaches for Acinetobacter infections The future approach for this MDR organisms.
US-Japan Cooperative Medical Sciences Program’s Virtual Workshop on COVID-19
Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released. US–Japan Cooperative Medical Sciences Program’s Virtual Workshop on COVID-19 Yohei Doi, Ken Ishii, Akira Nishizono, Asuka Nanbo, Shuzo Urata, Ichiro Kurane, Jules Carl Celebrado, John Philip Depatillo, Zymar Bandola, Diane E. Griffin, Eun-Chung Park, David McDonald, Kristina Lu, K.
Impact of Renal Impairment on Intensive Blood-Pressure-Lowering Therapy and Outcomes in Intracerebral Hemorrhage
Abstract Background and Objective The clinical effect of renal impairment on intracerebral hemorrhage (ICH) is unknown. This study sought to assess whether estimated glomerular filtration rate (eGFR) affects clinical outcomes or modifies the efficacy of intensive systolic blood pressure (BP) control (target, 110–139 mm Hg) against the standard (target, 140–179 mm Hg) among patients with ICH. Methods We conducted post hoc analyses of ATACH-2, a randomized, 2-group, open-label trial.
Prevalence of mcr-1 in Colonized Inpatients, China, 2011–2019
Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.
Impact of Renal Impairment on Intensive Blood-Pressure-Lowering Therapy and Outcomes in Intracerebral Hemorrhage: Results From ATACH-2
July 01, 2021Research ArticleOpen Access View ORCID ProfileMayumi Fukuda-Doi, Haruko Yamamoto, Masatoshi Koga, Yohei Doi, Adnan I. Qureshi, Sohei Yoshimura, View ORCID ProfileKaori Miwa, Akiko Ishigami, Masayuki Shiozawa, Katsuhiro Omae, View ORCID ProfileMasafumi Ihara, Kazunori Toyoda First published July 1, 2021, DOI: https://doi.org/10.1212/WNL.0000000000012442 Abstract Background and Objectives: The clinical impact of renal impairment on intracerebral hemorrhage (ICH) is unknown.
Natural History of Asymptomatic SARS-CoV-2 Infection
To the Editor: Information on the natural history of asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains scarce.1-3 The outbreak of coronavirus disease 2019 (Covid-19) on the cruise ship Diamond Princess led to 712 persons being infected with SARS-CoV-2 among the 3711 passengers and crew members, and 410 (58%) of these infected persons were asymptomatic at the time of testing (see the Supplementary Appendix, available with the full text of this...
Extended-spectrum β-lactamase-producing Escherichia coli
1 Michaela JD Katie LH David WW et al. Extended-spectrum β-lactamase-producing Escherichia coli in human-derived and foodchain-derived samples from England, Wales, and Scotland: an epidemiological surveillance and typing study. Lancet Infect Dis.
New Treatment Options against Carbapenem-Resistant Acinetobacter baumannii Infections
Minireview Burcu Isler, Yohei Doi, Robert A. Bonomo, David L. Paterson DOI: 10.1128/AAC.01110-18 ABSTRACT Carbapenem-resistant Acinetobacter baumannii (CRAB) is a perilous nosocomial pathogen causing substantial morbidity and mortality. Current treatment options for CRAB are limited and suffer from pharmacokinetic limitations, such as high toxicity and low plasma levels. As a result, CRAB is declared as the top priority pathogen by the World Health Organization for the investment in new drugs.
Hypervirulent Klebsiella pneumoniae: a Call for Consensus Definition and International Collaboration
TEXTKlebsiella pneumoniae infections have mainly been observed among hospitalized or immunocompromised patients, but clinicians in Taiwan first recognized an increasing number of pyogenic K. pneumoniae infections in the 1980s occurring among community-residing individuals without apparent immunodeficiency other than diabetes mellitus or anatomical abnormalities in biliary tracts (1, 2).
Elimination of Antibiotic Resistant Surgical Implant Biofilms Using an Engineered Cationic Amphipathic Peptide WLBU2
Infection remains an enormous clinical challenge in the field of surgery, and greatly increases the risk of morbidity and mortality for the patient. Total knee arthroplasty or knee replacement surgery provides an example of this dilemma. Given its success and cost feasibility, total knee arthroplasty has become one of the largest major surgical procedures by volume in the United States1,2. However, infection remains the most serious and costly reason for total knee arthroplasty failure3,4.
MCR-1-producing Klebsiella pneumoniae outbreak in China
In January, 2017, The Lancet Infectious Diseases published our finding1 that Enterobacteriaceae carrying mcr-1, a plasmid-mediated colistin resistance gene, are highly heterogenous in sequence type (ST) grouping and plasmid types indicating the diversity of mcr-1-carrying bacteria in China, and mcr-1-positive Enterobacteriaceae infections were associated with male sex, immunosuppression and antibiotics use before hospitalisation.
Possible Transmission of mcr-1-Harboring Escherichia coli between Companion Animals and Human
To the Editor: Plasmid-mediated, colistin-resistance mechanism gene mcr-1 was first identified in Escherichia coli isolates from food, food animals, and human patients in November 2015 (1). Reports on detection of mcr-1 in Enterobacteriaceae from humans and food animals soon followed from ≈12 countries (2–5). Here we report detection of mcr-1 in colistin-resistant E. coli isolated from companion animals and the possible transmission of mcr-1–harboring E. coli between companion animals and a person.
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