Yosef Kaplan Dor

Highlights • Sleep deprivation leads to ROS accumulation in the fly and mouse gut • Gut-accumulated ROS trigger oxidative stress in this organ • Preventing ROS accumulation in the gut allows survival without sleep in flies Summary The view that sleep is essential for survival is supported by the ubiquity of this behavior, the apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep loss can be lethal. The cause of this lethality is unknown.

Afonso D.J. Liu D. Machado D.R. Pan H. Jepson J.E. Rogulja D. Koh K. TARANIS Functions with Cyclin A and Cdk1 in a Novel Arousal Center to Control Sleep in Drosophila. Curr. Biol. 2015; 25: 1717-1726 Aiello L.C. Wheeler P. The Expensive Tissue Hypothesis: the brain and the digestive system in human and primate evolution. Curr. Anthropol. 1995; 36: 199-221 Ali T. Choe J. Awab A. Wagener T.L. Orr W.C. Sleep, immunity and inflammation in gastrointestinal disorders. World J. Gastroenterol.