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Articles by Yu An
Condensed Matter > Mesoscale and Nanoscale Physics
Graphene nanoscrolls form a unique radial superlattice whose geometry enables transport behaviors distinct from their flat counterparts. We theoretically demonstrate that rolling a graphene nanoribbon into a few-turn nanoscroll (1.0-1.2 turns) triggers a giant enhancement in longitudinal conductance by an order of magnitude (nearly twentyfold).
De novo variants in the poly(rC)-binding protein gene PCBP1 cause a neurodevelopmental disorder
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Abstract Poly(rC)-binding protein 1 (PCBP1), a splicing factor and key member of the hnRNP E family, was initially characterized for its tumor suppressive properties. More recently, its role in gene regulation in the brain and nervous system has attracted growing interest. Through an international multicenter collaboration, we identified 16 de novo pathogenic variants in PCBP1 across 17 subjects from 16 unrelated families.
By Wallid Deb, Thomas Besnard, Benjamin Cogné, Virginie Vignard, Sylviane Marouillat, Louis Januel, Svetlana Gorokhova, Tiffany Busa, Victor Morel, Benjamin Dauriat, Vincent des Portes, Eyyup Uctepe, Ozlem Dogan, Ahmet Yesilyurt, Yasemin Alanay, Anne M. Slavotinek, Yu An, Hane Lee, Peter Kannu, Taryn Athey, Marjon van Slegtenhorst, Patricia A. Dickson, Rachel Slaugh, Fadi F. Hamdan, Jean-Francois Soucy, Jacques L. Michaud, Alison M. Muir, Rebecca Buchert, Tobias B. Haack, Sérgio Sousa, Belinda Campos-Xavier, Pedro Almeida, Borut Peterlin, Sophie Kaspar, Christian Netzer, Hans Zempel, Meghan Towne, Lina Quteineh, Romane Meurs, Stylianos E. Antonarakis, Pawel Gawlinski, Xiaofei Song, Wojciech Wiszniewski, Daniel G. Calame, Jennifer E. Posey, Frédéric Ebstein, James R. Lupski, Bertrand Isidor, Stéphane Bézieau, Frédéric Laumonnier, Sébastien Küry, Florence Desprez, Jessy Hary, Ingrid M. B. H. van de Laar, Dominic Imort, Roger L. Ladda
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Nature
Verified
Advances in Plant-Based Cream Preparation Technology and Quality Formation Mechanisms
Plant-based cream is an important alternative to dairy products, gaining increasing attention for its health and nutritional benefits. Its primary components include plant proteins (such as soy protein and pea protein), plant oils, water, and emulsifiers. Therefore, understanding the mechanisms underlying the formation of plant-based cream quality can help regulate its quality characteristics through structural and functional properties.
Non-pharmacological therapies for sleep and occupational stress regulation among nightshift nurses: a systematic review and Bayesian network meta-analysis based on randomized controlled trials
Abstract Purpose: Nightshift nurses commonly suffer from sleep disturbances and occupational stress due to irregular work-sleep rhythms. This Bayesian network meta-analysis (NMA) compared the efficacy of non-pharmacological therapies to identify optimal interventions for improving sleep and reducing occupational stress in night/rotating-shift nurses. Methods: Cochrane, Embase, PubMed, Web of Science, and CNKI were searched up to October 24, 2025. Studies were assessed for bias via ROB2.
Impact of NRSN2 deficiency on memory: Altered excitatory synaptic plasticity associated with reduced expression of NMDA receptor subunits and impaired LTP in the hippocampus
Abstract Our earlier human studies identified NRSN2 (Neurensin-2), a neuronal-specific vesicular protein, as a candidate gene contributing to 20p13 microdeletion syndrome, yet the functional consequences of NRSN2 deficiency in the nervous system remain poorly understood.
Serum Short-Chain Fatty Acid Profiles as Metabolic Signatures of Diabetic Cognitive Impairment: Multinomial Modelling and Internally Validated Multiclass Discrimination
J.Zheng, Y.An, X.Zhang, et al., “Serum Short-Chain Fatty Acid Profiles as Metabolic Signatures of Diabetic Cognitive Impairment: Multinomial Modelling and Internally Validated Multiclass Discrimination,” Diabetes, Obesity and Metabolism (2026): 1–13, https://doi.org/10.1111/dom.70656. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data used to support the results of this study are available from the corresponding author on reasonable request.
Geoeconomic Competition and Capital Reallocation in Global FX Funding
We thank Chris Clayton, Ben Hébert, and Arvind Krishnamurthy for helpful discussions. We also thank participants at NBER Financial Market Frictions, ECB, Wharton, and Drexel for comments. We gratefully acknowledge funding from the NBER-OFR Grant on Financial Frictions and Systemic Risk, the Jacobs Levy Equity Management Center for Quantitative Financial Research, and the General Research Support Fund at Johns Hopkins Carey Business School.
Intelligent Data‐Driven Framework for Fuel Consumption Prediction in Price Commitment Scenarios
Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. References 1 7 Eleven Australia, “ My 7-Eleven App Fuel Price Lock Terms and Conditions,” 2024, https://www.7eleven.com.au/mobile/my-7-eleven-app-fuel-price-lock-terms-and-conditions.html.
Anti-interference chaotic laser ranging by using ultrafast noise-like pulses
The growing demands of light detection and ranging (LiDAR) toward various application scenarios have aroused intensive research on laser ranging technologies. Beyond coherent laser states, the chaotic counterpart with natural random modulations paves a critical way for advanced ranging schemes due to their excellent anti-interference capabilities and absence of range ambiguity. Here, we propose a ranging system based on noise-like pulses.
Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism
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Keywords diurnal rhythm genetic variation 3D enhancer-promoter interaction metabolic disorders human metabolic traits Get full text access Log in, subscribe or purchase for full access. References 1. Allada, R. ∙ Bass, J. Circadian Mechanisms in Medicine N. Engl. J. Med. 2021; 384:550-561 2. Guan, D. ∙ Lazar, M.A. Interconnections between circadian clocks and metabolism J. Clin. Invest. 2021; 131, e148278 3. Bass, J. ∙ Lazar, M.A. Circadian time signatures of fitness and disease Science. 2016; 354:994-999 4.
By Dishu Zhou, Ying Chen, Kun Zhu, S. Lloyd, Inna I. Astapova, Ying Xiong, Hosung Bae, Marlene Lucia Aguilar, Hongyuan Yang, Yu An, Zheng Sun, Mark Herman, Xia Gao, Liming Pei, Cholsoon Jang, Joshua D. Rabinowitz, Samer G. Mattar, Yongyou Zhang, Dongyin Guan, Juliet Holder-Haynes, Seunghee Choa, Juliet Holder-Haynes, Seunghee Choa
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Cell Metabolism
Verified
A Case of Prader‐Willi Syndrome With a Deletion Including MAGEL2 , NDN , and MKRN3 , but Excluding SNRPN and SNORD116
1 Introduction Prader-Willi syndrome (PWS) is a neurodevelopmental disorder characterized by neonatal hypotonia, developmental delay, obesity, hyperphagia, and behavioral issues, among other features (Holm et al. 1993).
Impact of Split Nitrogen Topdressing on Rhizobacteria Community of Winter Wheat
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Nitrogen and Phosphorus Stoichiometry of Bolboschoenus planiculmis Plants in Soda-Alkali Wetlands Undergoing Agricultural Drainage Water Input in a Semi-Arid Region
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Child abuse in S'pore & what can be done to prevent such cases
Content warning: Some readers may find the descriptions and photos in this article graphic and triggering. Discretion is advised. MS Explains: How are children in Singapore protected from abuse? This piece is part of MS Explains, a segment where we provide clarity to common or key topics, making them easier to digest. – On 21 Feb, a father in Taiwan was sentenced to 18 years in jail after abusing and killing his child.
SERPINA3: A Novel Therapeutic Target for Diabetes-Related Cognitive Impairment Identified Through Integrated Machine Learning and Molecular Docking Analysis
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Real Estate Economics | AREUEA Journal | Wiley Online Library
REFERENCES , , & (2012). Adverse selection in mortgage securitization. Journal of Financial Economics, 105(3), 640–660. , , & (2005). Does regulatory capital arbitrage, reputation, or asymmetric information drive securitization? Journal of Financial Services Research, 28(1), 113–133. , , & (2016). Credit rationing, income exaggeration, and adverse selection in the mortgage market. Journal of Finance, 71(6), 2637–2686. , , , & (2019). Risk and performance of mutual funds' securitized mortgage investments.
Comprehensive pan-cancer analysis identifies IGFL1 as an oncogenic bio
Back to Journals » International Journal of General Medicine » Volume 18 Original Research Oncology Authors Liang Z, An Y, He J, Zhu Z, Jiang K, Chen K , Sun F Received 7 February 2025 Accepted for publication 10 July 2025 Published 15 July 2025 Volume 2025:18 Pages 3881—3900 DOI https://doi.org/10.2147/IJGM.S517611 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Ching-Hsien Chen Zongjian Liang,1,* Yu...
The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice
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Keywords GIP receptor adipose tissue obesity weight loss energy expenditure SERCA pathway Introduction The prevalence of obesity has substantially increased.
By Xinxin Yu, Shiuhwei Chen, Jan-Bernd Funcke, Leon G. Straub, Valentina Pirro, Margo P. Emont, Brian A. Droz, Kyla AI. Collins, Chanmin Joung, Mackenzie J. Pearson, Corey James, Gopal J. Babu, Vissarion Efthymiou, Ashley Vernon, Mary Elizabeth Patti, Yu An, Evan Rosen, Matthew Coghlan, Ricardo J. Samms, Philipp E. Scherer, Christine M. Kusminski
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Cell Metabolism
Verified
Canadian man with S’pore job offer worried after parents warn he may face charges for defaulting NS
Man worried as S’porean parents convinced he would be arrested for defaulting NS A Canadian man has found himself in a peculiar situation after his Singaporean parents tried to dissuade him from taking up a job offer in Singapore by convincing him he had defaulted on National Service (NS). Although he received assurances from Singapore authorities that he has no NS obligations, his parents remain convinced otherwise, claiming he could face arrest upon entering the country.
Beggar near Waterloo Street presumably earns S$10 in 5 minutes, sparks debate
Beggar sparks debate earning S$10 in 5 minutes near Waterloo Street A netizen recently witnessed a beggar on Waterloo Street who earned S$10 within five minutes of asking passersby for cash. The netizen, frustrated by how easily the beggar had obtained money, shared the encounter on the Complaint Singapore Facebook page on Wednesday (18 Dec). “In 5 mins earn $10. Guess how much he earns a day,” wrote the OP. “Better income than some doctors, accountants or lawyers.
Underage teen in S’pore gives birth to dead baby & buries him in house yard, police digs up bones during investigation
Crime Latest News Underage mother buries dead baby in house yard An underage teen in Singapore gave birth to a dead baby and buried the body in her house yard. The incident, which occurred in June 2021, only came to light when the teen made a police report 10 months later. By the time authorities exhumed the remains, the baby’s body had been reduced to bones. A coroner officially opened an inquiry into the case on Monday (23 Dec).
80% of people polled not comfortable with unmasking NRIC number
Poll: 80% majority uncomfortable with unmasking NRIC number Last Friday (13 Dec), veteran journalist Bertha Henson wrote a Facebook post stating that Accounting and Corporate Regulatory Authority’s (ACRA) newly launched Bizfile had made many individuals’ full NRIC numbers publicly accessible through a search of their full names. The journalist’s initial revelation raised concerns among the population, and the function has since been made unavailable on Bizfile.
Car rams into guard rail & flips into drain along Tanglin Road, netizens ask if driver went to ‘flying academy’
Car skids into drain on Tanglin Road & lands in bizarre position On Thursday afternoon (18 Dec), a car collided with a guard rail and flipped into a drain along Tanglin Road, landing neatly between a lamppost and an electrical box. The police and Singapore Civil Defence Force reported no casualties, with the 46-year-old male driver sustaining only minor injuries. However, netizens were left baffled by how the car ended up in such an unusual position.
5 new F&B outlets to check out at Parkway Parade
Parkway Parade unveils 5 new F&B outlets, time to dig in When new eateries open, it’s always worth celebrating — finally, something fresh to shake up the usual dining spots. This time, easties, it’s your turn to get excited. Again. Parkway Parade, one of Singapore’s first major shopping malls, is rolling out five brand-new F&B outlets this month, each bringing something unique to the table.
Idol in Thailand performs while 36 weeks pregnant, netizens frightened about fetus’ health
36 weeks pregnant idol in Thailand performs on stage Pregnant mothers usually take great precautions in their daily activities, as a wrong step can end up harming both herself and the baby she’s carrying. However, for a Thai idol part of the girl group Girly Berry, pregnancy did not deter her from performing on stage — even when she was 36 weeks along. A post of her dancing during a concert in October recently went viral again on Instagram, garnering over 60,000 likes and close to 400 comments.
Money mule visits temple in Taiwan for good luck before meeting scam victim, arrested while praying
Money mule in Taiwan arrested while praying for smooth-sailing crime A 17-year-old was arrested in Taiwan last Friday (6 Dec) while praying for good luck before completing a criminal transaction. The unusual incident unfolded at a temple in Taipei, where the teenager had arranged to meet a scam victim to collect NT$1 million (S$41,500) in cash. However, the victim had been in contact with the police after noticing suspicious activity, and an ambush was set up at the temple.
S’pore singer creates local version of viral ‘APT’ song, amused netizens say “only S’poreans can understand”
‘S’porean APT’ draws buzz on TikTok for local version of hit song A local singer-songwriter has put a uniquely Singaporean spin on the viral song APT by ROSÉ and Bruno Mars, replacing the original version with words that hit close to home, such as “BTO” and “HDB.” The creative renditions by Sam Driscoll have gone viral on TikTok, amassing more than 200,000 views in just one week. Many netizens praised the songs for their hilariously relatable take on life in Singapore.
ACRA's Bizfile exposes NRIC numbers, veteran journalist Bertha Henson raises privacy concerns
Bertha Henson highlights NRIC exposure on ACRA’s Bizfile Veteran Singaporean journalist Bertha Henson has raised concerns over a privacy issue involving the Accounting and Corporate Regulatory Authority’s (ACRA) Bizfile platform, which has made individuals’ full NRIC numbers publicly accessible. On Thursday (12 Dec), Ms Henson shared the issue on her Facebook page, providing a detailed explanation of her findings.
Motorcyclist rides on road divider to overtake car in Teck Whye, some netizens praise his riding skills
Motorcyclist overtakes car using road divider Reckless riding is frowned upon and widely criticised in Singapore — most of the time. On Tuesday (10 Dec), a motorcyclist on a Scrambler overtook a vehicle on a single-lane using the road divider. However, apart from drawing some criticism, the motorcyclist also drew praise for putting his scrambler motorbike to good use. Video of the incident was uploaded onto SG Road Vigilante’s Facebook page, where it has since started discussions.
21-year-old daughter surprises mother in Genting, dies in accident when coming back to S’pore
Daughter dies in accident after surprising mother in Genting A tragedy happened on the morning of Tuesday (10 Dec). A 21-year-old woman who had travelled to Genting to surprise her mother died in a traffic accident on her way back to Singapore, merely four hours after meeting her mother. She was on her boyfriend’s motorcycle, and the two were rushing back to Singapore for a meeting.
Resident in S’pore pays for cash-on-delivery parcel bearing mother’s information, turns out nobody ordered it
Netizen shares experience with new type of parcel scam in Singapore A new type of parcel scam has been reported in Singapore. On Thursday (12 Dec), a victim of the scam took to Reddit to share their experience with a bizarre delivery that turned out to be a scam. The victim had paid for a parcel that listed their mother as the receiver when in fact, no such delivery was ordered. Prior to the delivery, the victim’s mother had received a message from Ninja Van about a scheduled delivery.
Python spotted outside HDB window in Jurong West, rescued by ACRES in 2 minutes
Python climbs up HDB in Jurong West On Sunday (8 Dec), a python was spotted climbing up the second-floor window of an HDB flat in Jurong West. Jurong West residents stunned when python appears outside their window byu/stevenlong10 insingaporehappenings Fortunately, there were no injuries reported. The resident of the unit managed to close the window in time, preventing the snake from entering.
‘Why aren’t you dead yet?’: Taiwan officer allegedly mocked woman before her suicide over wiped savings from scam
Police officer under investigation for abetting deaths after mother & daughter suicide in Taiwan On Sunday (8 Dec), a mother and daughter were found dead in their home in Taiwan’s Neihu District, in what is believed to be a case of double suicide. The pair reportedly took their own lives after losing their life savings to a sophisticated investment scam.
SCDF goes viral for ‘lalala dance trend’, netizens swoon over firefighters
SCDF swerves to the tunes of viral “lalala dance trend” If you are on TikTok, you have probably seen the recent ‘lalala dance’ trend, where the camera shakes a few times to a catchy beat before panning to different people busting out dance moves. Not one to fall behind the times, Singapore Civil Defence Force (SCDF) hopped on the trend and posted their own rendition of the ‘lalala dance’.
Furnish your new BTO with smart digital locks from S$299 & 5-star hotel-grade mattresses from S$799
Unlock ultimate comfort & security with My President Mattress & My Digital Lock After months of working with interior designers and contractors, your home renovation is finally complete. Now, there’s just one last thing to do before settling into your dream abode: furnishing it. As you explore various stores in search of the perfect pieces, be sure to add My President Mattress and My Digital Lock’s 12th-anniversary celebrations to your calendar.
S’pore cosplayer Rurusama offers fans exclusive feet view for S$1K, slaps also available for S$20
Cosplayer Rurusama charges fans S$1,000 to see her feet at Singapore Comic Con The Singapore Comic Con (SGCC) took place over the weekend from 7 to 8 Dec, drawing fans eager to engage with their favourite artists and creators. This year, one cosplayer took fan interaction to a new level by offering an exclusive view of her feet for S$1,000. The unusual offer came from Rurusama, one of Singapore’s most prominent cosplayers with 1.3 million followers on Instagram and 1.4 million on TikTok.
67-year-old man stabbed in the eye by neighbour in Hougang, nearly goes blind
67-year-old man stabbed in eye during dispute with neighbour A 67-year-old man was stabbed in his right eye with a metal pole during a dispute with his neighbour in Hougang, resulting in a serious eye injury that nearly left him blind. The victim suffered a conjunctival tear to his right eye and required two surgeries to retain his vision. Fortunately, the surgeries were successful, but he continues to experience
67-year-old man stabbed in the eye by neighbour in Hougang, nearly goes blind
67-year-old man stabbed in eye during dispute with neighbour A 67-year-old man was stabbed in his right eye with a metal pole during a dispute with his neighbour in Hougang, resulting in a serious eye injury that nearly left him blind. The victim suffered a conjunctival tear to his right eye and required two surgeries to retain his vision. Fortunately, the surgeries were successful, but he continues to experience discomfort and occasional discharge in the affected eye.
Teen in Turkey dies on video call with mother after allergic reaction to peanuts
Teen in Turkey dies after being served pudding with peanuts A 19-year-old tourist in Turkey has died from an allergic reaction to peanuts while having pudding at a restaurant. He had checked with the waiter three times whether the dessert contained the allergen, and each time the waiter confirmed that it was not present. However, he started having an allergic reaction after a few bites into the pudding.
‘I have a mum now’: Firefighter in China breaks down after seeing photo of mother who died when he was 3
International Latest News One netizen suggested that his mother must have also tried to imagine what he would become as an adult. By Yu An - 6 Dec 2024, 3:31 pm
Firefighter in China breaks down after seeing photo of mother who died when he was 3
Firefighter in China finds photo of deceased mother A 33-year-old firefighter in Zhejiang, China recently touched many hearts with his reaction to finding a photo of his late mother through local authorities. His mother passed away when he was just three, leaving him too young to remember what she looked like. Seeking answers, the firefighter reached out to the authorities, who were able to find a photo of her for him.
17-year-old student who died before M'sian national exam had excellent results, scored 10A1B in prelims
International Latest News Malaysian student who died before national exam had excellent results The 17-year-old student who died before she could take the Malaysian Certificate of Education (SPM) national exam had achieved excellent results in her preliminary tests, scoring 10 As and one B. According to her parents, who spoke to Sin Chew Daily, the girl was always hardworking and driven in her studies.
Man who kidnapped 15-year-old in M’sia is an NUS student, pleads not guilty & denied bail
NUS student charged for kidnapping 15-year-old The suspect arrested for kidnapping a 15-year-old girl in Malaysia has been revealed as a 22-year-old student from the National University of Singapore (NUS). Originally from Guangdong, China, the defendant appeared in a Johor court on Thursday (5 Dec), where he pleaded not guilty to the charges. According to Oriental Daily, the defendant, who was escorted by several police office...
Man who kidnapped 15-year-old in M'sia is an NUS student, pleads not guilty & denied bail
NUS student charged for kidnapping 15-year-old The suspect arrested for kidnapping a 15-year-old girl in Malaysia has been revealed as a 22-year-old student from the National University of Singapore (NUS). Originally from Guangdong, China, the defendant appeared in a Johor court on Thursday (5 Dec), where he pleaded not guilty to the charges.
Man who allegedly kidnapped 15-year-old in M'sia is a S'pore uni student, pleads not guilty & denied bail
Man accused of kidnapping 15-year-old is S’pore uni student The suspect arrested for kidnapping a 15-year-old girl in Malaysia has been revealed as a 22-year-old student studying in a university in Singapore. Originally from Guangdong, China, the defendant appeared in a Johor court on Thursday (5 Dec), where he pleaded not guilty to the charges.
Two S'porean men smuggle 130L of cough syrup from M'sia using luxury yacht, arrested in JB
Two Singaporean men arrested for smuggling cough syrup On Tuesday (3 Dec), two Singaporean men were arrested in Johor, Malaysia, for smuggling a large quantity of cough syrup. According to local authorities, the men smuggled the drugs using a luxury yacht while pretending to ferry customers on fishing trips. A total of 130 litres of cough syrup, valued at RM75,150 (S$22,760), was seized during the operation. The arrests took place when police raided a dock in Masai, Johor.
Cosmetics entrepreneur in M'sia goes viral for spreading positivity while standing chin-deep in floodwater
Cosmetics entrepreneur spreads positivity while standing in floodwater As Malaysia continues to grapple with severe flooding, a cosmetics entrepreneur has made waves by stepping up to spread positivity in the face of devastation. In a reel posted by Facebook user Tengku Shah, the woman is seen wading through chin-deep floodwaters in front of a row of houses.
Universal Traveller Mega Expo Sale has winter jackets from S$39, so the cold won’t bother you anyway
Get ready for your winter adventure at the Universal Traveller Mega Expo Sale The year-end holidays are finally here. If you’re one of the lucky ones jetting off to a winter wonderland (or any destination that calls for a little extra warmth), it’s time to prep for an adventure that’s as stylish as it is cosy. From 6 to 8 Dec, Universal Traveller’s Mega Expo Sale is your ultimate pre-flight checklist.
Floodwater in M'sia turned red apparently due to food colouring from chilli sauce factory
Malaysia sees unsettling sea of red floodwater A video depicting red floodwaters in Malaysia recently viral on TikTok, garnering over a million views within three days. The video, taken in Kelantan, Malaysia, shows floodwater in a strange red hue, unsettling many netizens. @azamjusoh ♬ Musim Hujan ( Do’a ) – gondrong The country has been battling with severe flooding the past week due to torrential rainfall, which saw six months’ worth of rainfall within five days.
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