Dongyin Guan

Abstract Histone deacetylase inhibitors (HDIs) are approved for treating hematologic cancers and are currently being evaluated in hundreds of clinical trials for various cancers and other diseases, although their mechanisms of action remain poorly understood.

Keywords diurnal rhythm genetic variation 3D enhancer-promoter interaction metabolic disorders human metabolic traits Get full text access Log in, subscribe or purchase for full access. References 1. Allada, R. ∙ Bass, J. Circadian Mechanisms in Medicine N. Engl. J. Med. 2021; 384:550-561 2. Guan, D. ∙ Lazar, M.A. Interconnections between circadian clocks and metabolism J. Clin. Invest. 2021; 131, e148278 3. Bass, J. ∙ Lazar, M.A. Circadian time signatures of fitness and disease Science. 2016; 354:994-999 4.

Abstract Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a promising source of new pharmaceuticals, yet the therapeutic potential of fungal RiPPs remains largely underexplored. Here we report asperigimycins as a distinct class of fungal RiPPs, featuring a unique heptacyclic scaffold consisting of a benzofuranoindoline core and three additional macrocycles, primarily assembled by six distinct fungi-specific DUF3328 oxidases.