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Articles by Yu Chang
Case Report: Pulmonary artery banding for an older child with end-stage dilated cardiomyopathy
Abstract Therapeutic options for children with end-stage dilated cardiomyopathy are limited. Pulmonary artery banding has been proposed as a potential bridge or alternative strategy in children with severe left ventricular dysfunction and preserved right ventricular function, but related experience in older children is limited.
Catalytic asymmetric dearomatization of (hetero)aromatic frameworks
Abstract Catalytic asymmetric dearomative cycloaddition provides a powerful route to polycyclic chiral frameworks, yet the precise control of selectivity in such cycloadditions remains a formidable challenge. Herein we report a mechanism-guided strategy that harnesses the unique reactivity of vinylidene ortho-quinone methides as highly reactive and multifunctional synthons to realize such cycloaddition with diverse (hetero)polycyclic aromatics.
Associations between financial fraud victimization and depressive symptoms, loneliness, and suicidality among young adults in Taiwan: Moderating effects of working memory and inhibitory control deficits.
Background: Most studies on financial fraud have focused on older adults. The experiences of financial fraud victimization and their associations with mental health problems among young adults warrant further investigation. The present study examined the associations between financial fraud victimization and depressive symptoms, loneliness, and suicidality, as well as the moderating effects of working memory and inhibitory control deficits on these associations in young adults.
The association between proton pump inhibitors use on outcomes following carotid endarterectomy for carotid stenosis: a population-based cohort study
Abstract Carotid endarterectomy (CEA) is effective in treating carotid stenosis and preventing future stroke. Proton pump inhibitor (PPI) is frequently prescribed among the general population. However, the association of PPI use on outcomes following CEA for carotid stenosis remains unclear. This is a retrospective, propensity-matched analysis conducted using the TriNetX research network.
Warm intranasal saline irrigation reduces intraoperative blood loss during functional endoscopic sinus surgery: a propensity score-matched cohort study
Abstract Background To evaluate whether warm intranasal saline irrigation (38–40 °C) during functional endoscopic sinus surgery (FESS) is associated with reduced intraoperative bleeding compared with standard cold irrigation (18–21 °C). Methods We performed a single-centre retrospective cohort study of consecutive FESS procedures under inhalational general anaesthesia (January 2017–December 2022). After exclusions, 1,990 cases were eligible.
An integrated modeling method for rainfall-induced geohazard chains: coupling landslide mobilization and flow-state transition
Abstract Extreme rainfall in mountain catchments can trigger shallow landslides, debris flows, and sediment-laden floods as interconnected geohazard chains. This study proposes a coupling-oriented modeling framework that links rainfall-induced landslide-source mobilization with downstream flow-state transition.
Risk of Psychiatric Worsening With GLP-1 Receptor Agonist Use in Patients With Type 2 Diabetes and Treated Depression
Filename Description dom70927-sup-0001-Supinfo.docxWord 2007 document , 327 KB Table S1: STROBE checklist for cohort studies for the current study. Table S2: Cohort, outcome and covariate definition codebook for the primary analysis. Table S3: Baseline covariate balance before and after matching in the primary 1-year analysis. Table S4: Follow-up summaries before and after matching. Table S5: E values for the main 1-year outcomes.
Residual cholesterol correlates with mild cognitive impairment, particularly for executive dysfunction among male individuals with type 2 diabetes mellitus
Abstract Background: Residual cholesterol (RC) is derived from lipids, especially for cholesterol metabolism indexes, correlated with excessive nutrient intake, has recently been suggested to influence cognitive function. It not only reflects the nutrition metabolism status, but also is closely associated with diabetic complications. Despite this, how this nutrition-related metabolic marker relates to cognitive dysfunction in type 2 diabetes mellitus (T2DM) patients is still poorly understood.
Attenuating Imine Bond Polarization in Covalent Organic Frameworks Accelerates Charge and Proton Transport for High-Efficiency Photocatalytic Hydrogen Evolution Click to copy article link Article link copied!
Cite Jump to ExpandCollapse ArticleMay 13, 2026 Attenuating Imine Bond Polarization in Covalent Organic Frameworks Accelerates Charge and Proton Transport for High-Efficiency Photocatalytic Hydrogen Evolution Click to copy article linkArticle link copied! Zhipeng Luo Zhipeng Luo State Key Laboratory of Chemistry for NBC Hazards Protection, College of Chemistry, Fuzhou University, Fuzhou 350116, P. R.
Tailoring CSR based on relational networks with stakeholders
Abstract This study examines corporate social responsibility (CSR) through relational networks involving internal, external, and social stakeholders. The empirical analysis uses panel data from 152 Korean listed firms between 2019 and 2021, combining ESG ratings from the Korea Institute of Corporate Governance and Sustainability (KCGS) with financial data (KIS-VALUE) provided by NICE Information Service.
Machine learning–driven discovery of optimal designs for water electrolysis devices
Abstract Green hydrogen production via water electrolysis is key to decarbonizing energy systems, but current electrolyzer designs are energy-intensive due to gas bubble entrapment and manual optimization. This study introduces a machine learning (ML) strategy that autonomously designs high-efficiency electrolyzer flow channels.
Association of carotid revascularization with epilepsy and seizures in patients with carotid stenosis
CONFLICT OF INTEREST STATEMENT None of the authors has any conflict of interest to disclose. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. DATA AVAILABILITY STATEMENT The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
Frontiers | Establishment and validation of a clinical prediction model for perioperative pneumonia in elderly patients with hip fractures combined with preoperative stroke
Abstract Background: Hip fractures in the elderly are associated with alarmingly high disability and mortality rates, which severely impair patients’ quality of life. Patients with a history of stroke face a significantly increased risk of perioperative pneumonia and a threefold higher risk of death. This study aimed to establish a clinical prediction model for perioperative pneumonia in elderly patients with hip fractures and preoperative stroke.
A first‐line regimen combining Bruton's tyrosine kinase and programmed cell death protein‐1 inhibitors with chemotherapy excluding methotrexate achieves high response rates in primary central nervous system lymphoma
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description cncr70247-sup-0001-suppl-data.docx190.2 KB Supplementary Material REFERENCES 1, . Primary CNS lymphoma. J Clin Oncol. 2017; 35(21): 2410-2418. doi:10.1200/jco.2017.72.7602 2, , , .
Stereoselective Dihalogenation of Alkynes to Access Enantioenriched Z-Vicinal Dihaloalkene Atropisomers
Cite Jump to ExpandCollapse ArticleDecember 30, 2025 Stereoselective Dihalogenation of Alkynes to Access Enantioenriched Z-Vicinal Dihaloalkene Atropisomers Click to copy article linkArticle link copied! Yu Chang Yu Chang Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, P. R.
Cumene Oxidation Process Intensification in a Countercurrent Microbubble Column Reactor
Abstract Click to copy section linkSection link copied! Cumene oxidation process, as a vital industrial reaction for the production of phenol and acetone, faces several significant challenges including a huge reactor volume, high safety risk, and substantial VOC (volatile organic compounds) emission. This work identifies the underlying reasons for large bubble sizes and broad bubble size distributions within conventional bubble reactors.
Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis
Multiple sclerosis is a disorder of the central nervous system (CNS) in which autoreactive immune cells migrate through a damaged blood brain barrier, resulting in focal demyelinating lesions. Beyond focal lesions, there are also diffuse surface-in gradients of pathology in MS, wherein damage is most severe directly adjacent to cerebrospinal fluid (CSF)-contacting surfaces, such as the subpial and periventricular areas.
Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics
4C-seq chromosome conformation capture followed by high-throughput sequencing CRE cis-regulatory elements DLPFC dorsolateral prefrontal cortex GREAT Genomic Regions Enrichment of Annotations Tool NAD nicotinamide adenine dinucleotide NMNAT2 nicotinamide mononucleotide adenylyltransferase 2 ROSMAP Religious Orders Study and the Rush Memory and Aging Project TFs transcription factors Introduction Cell type-specific transcriptomic analysis reveals the importance of transcriptional regulation in...
Frontiers | Sex differences in the association between the uric acid to high density lipoprotein cholesterol ratio and mild cognitive impairment in patients with type 2 diabetes mellitus
ORIGINAL RESEARCH article Volume 12 - 2025 | https://doi.org/10.3389/fnut.2025.1667948 This article is part of the Research TopicNutrient Metabolism and Complications of Type 2 Diabetes MellitusView all 27 articles 1 Introduction The global incidence of type 2 diabetes mellitus (T2DM) has been steadily increasing.
Machine learning for detecting iron deficiency through comprehensive blood analysis
Listen to the Clinical Chemistry Podcast Article Yu-Hsin Chang, Chia-Yu Chen, Chiung-Tzu Hsiao, Yu-Chang Chang, Hsin-Yu Lai, Hsiu-Hsien Lin, Ya-Lun Wu, Chien-Chih Chen, Lin-Chen Hsu, Tzu-Ting Chen, Hong-Mo Shih, Po-Ren Hsueh, Der-Yang Cho. Machine Learning for Detecting Iron Deficiency through Comprehensive Blood Analysis. Clin Chem 2025; 71(9): 949–61. Guest Dr. Yu Hsin Chang is an attending physician in the Emergency Department at China Medical University Hospital in Taiwan.
Microrchidia ATPases and DNA 6mA demethylase ALKBH1 act antagonistically on PRC2 to control chromatin structure and stress tolerance - Nature Plants
Abstract The Microrchidia (MORC) proteins are conserved GHKL-type ATPases required for chromatin condensation and gene silencing in animals and plants. Here we show that MORC proteins function with Polycomb-Repressive Complex 2 (PRC2) to control chromatin structure, gene expression and stress responses in rice.
Evaluating chatbots in psychiatry: Rasch-based insights into clinical knowledge and reasoning
First, we performed descriptive analysis, including calculations of the mean, standard deviation, maximum and minimum scores, and Cronbach’s alpha to assess the internal consistency of the test. We then conducted further analysis using the Rasch model, a statistical method widely used in psychometrics to evaluate the relationship between item difficulty and the ability of respondents.
Why Browser Games Are Surpassing Premium Platforms - From a Developer's Perspective
In recent years, the gaming industry has been dominated by high-budget, premium platforms — think PlayStation, Xbox, or Steam. But in 2025, we’re witnessing a quiet shift: browser-based games are not only catching up, but in many ways surpassing traditional platforms — in accessibility, reach, and technical elegance. As a full-stack developer and indie builder, I recently launched PlayCrazyGames.io — a multilingual HTML5 gaming platform.
CDK12/13 inactivation triggers STING-mediated antitumor immunity in preclinical models
Abstract Inactivation of cyclin-dependent kinase 12 (CDK12) defines an immunogenic molecular subtype of prostate cancer characterized by genomic instability and increased intratumoral T cell infiltration. This study revealed that genetic or pharmacologic inactivation of CDK12 and its paralog CDK13 robustly activates stimulator of interferon genes (STING) signaling across multiple cancer types.
Anticoagulants for Atrial Fibrillation in Survivors of Intracranial Hemorrhage: A Meta-Analysis of Randomized Trials
Get full access to this article View all available purchase options and get full access to this article. References 1. Hart R.G., Pearce L.A., Aguilar M.I. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 2007;146:12: 857-867. 2. Al-Shahi Salman R., Stephen J., Tierney J.F., et al.
Unveiling the Molecular Landscape of MPO in Kikuchi's Disease: Protein Expression, mRNA Levels, and Genetic Polymorphisms
1 Introduction Kikuchi's disease, also known as histiocytic necrotizing lymphadenitis (HNL), is a benign, self-limiting disease that affects young women, with a high incidence in Asia and an increasing trend in recent years. The etiology and pathogenesis of Kikuchi's disease are unknown, but some studies suggest it is associated with viral infection or autoimmune disease [1].
Organocatalytic C─O Bond Cleavage and Asymmetric Transformations via [1,3]‐Sigmatropic Rearrangement
1 Introduction The development of atom-economical procedures for stereoselectively constructing chiral building blocks represents one of the key issues in the field of organic synthesis.[1] Great efforts have been made in the past decades and tremendous advances have been achieved to reach this goal. While there are still some crucial fundamental issues that need to be addressed, to overcome the obstacles involving harsh reaction conditions, costly materials, and lengthy synthetic processes.
Validating Khorana Risk Score in gastric cancer patients on immune checkpoint inhibitors and chemotherapy
ABSTRACT Introduction Patients with gastric cancer are at a high risk of venous thromboembolism (VTE), and immune checkpoint inhibitors (ICIs) may further increase this risk. While the Khorana Risk Score (KRS) has been validated primarily in chemotherapy-treated populations, its utility in ICI-treated patients remains unclear.
Letter to the Editor. Minimally invasive versus open surgery for spine metastases
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Flexible iontronic sensing
Flexible iontronic sensing The emerging flexible iontronic sensing (FITS) technology has introduced a novel modality for tactile perception, mimicking the topological structure of human skin while providing a viable strategy for seamless integration with biological systems.
An Efficient Simplified SPAD Timing Jitter Model in Verilog-A for Circuit Simulation
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Soil Nutrients in Sandy Plantations Are Related to the Species, Diameter at Breast Height or at Base, and Distance from the Tree Base in Horqin
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Multiple roles of NAC transcription factors in plant development and stress responses
CONFLICTS OF INTEREST The authors declare they have no conflict of interest. Supporting Information Additional Supporting Information may be found online in the supporting information tab for this article: http://onlinelibrary.wiley.com/doi/10.1111/jipb.13854/suppinfo Filename Description jipb13854-sup-0001-Supplemental_table_1.docx55.5 KB Table S1. Summary of NACs (NAM, ATAF1/2, and CUC2) involved in plant growth and development jipb13854-sup-0002-Supplemental_table_2.docx58.5 KB Table S2.
Dengue Virus Replicative‐Form dsRNA Is Recognized by Both RIG‐I and MDA5 to Activate Innate Immunity
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description jmv70194-sup-0001-Ye_DENV_PAMP-SM-JMV-R1.doc1.2 MB Supporting information. References 1 and , “The Origin, Emergence and Evolutionary Genetics of Dengue Virus,” Infection, Genetics and Evolution 3, no. 1 (2003): 19–28.
German and Taiwanese secondary students’ mathematical modelling task value profiles and their relation to mathematical knowledge and modelling performance
Ayuda Buscar en la ayuda Buscar en la ayuda German and Taiwanese secondary students’ mathematical modelling task value profiles and their relation to mathematical knowledge and modelling performance Autores: Kai Lin Yang, Janina Krawitz, Stanislaw Schukajlow, Chai Ching Yang, Yu Ping Chang Localización: European journal of psychology of education, ISSN-e 1878-5174, ISSN 0256-2928, Vol. 39, Nº 3, 2024, págs.
Insights into the Metabolism, Disposition, and Quantitative Profile of mGlu5 NAM AE90015 with Metabolite Identification and a Novel Integration Method
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Multiple Instance Bagging and Risk Histogram for Survival Time Analysis Based on Whole Slide Images of Brain Cancer Patients
1. Introduction Glioblastoma multiforme (GBM), among the most malignant central nervous system tumors, constitutes a prevalent form of primary brain cancer originating within brain tissue. Studies indicate challenges in complete tumor removal during surgery due to its inherent local invasiveness, with a probability of recurrence in the vicinity of the original tumor location. Its aggressive nature bears a grade IV classification and a bleak prognosis [1].
Assessing the Performance of Chatbots on the Taiwan Psychiatry Licensing Examination Using the Rasch Model
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Transcriptional Regulation of human NMNAT2: Insights from 3D Genome Sequencing and Bioinformatics
Abstract Nicotinamide mononucleotide adenylyl transferases 2 (NMNAT2) is a crucial nicotinamide adenine dinucleotide (NAD)-synthesizing enzyme essential for neuronal health. In the Religious Orders Study/Memory and Aging Project (ROSMAP), human brain levels of NMNAT2 mRNA positively correlated with cognitive capabilities in older adults. NMNAT2 mRNA abundance is significantly reduced following various insults or proteinopathies.
Dengue virus replicative-form dsRNA is recognized by RIG-I and MDA5 cooperatively to activate innate immunity
Abstract RIG-I like receptors (RLRs) are a family of cytosolic RNA sensors that sense RNA virus infection to activate innate immune response. It is generally believed that different RNA viruses are recognized by either RIG-I or MDA5, two important RLR members, depending on the nature of pathogen-associated molecular patterns (PAMPs) that are generated by RNA virus replication. Dengue virus (DENV) is an important RNA virus causing serious human diseases.
Associations of artificial sweetener intake with cardiometabolic disorders and mortality: a population-based study
Artificial sweeteners have been widely employed as sugar substitutes in the food industry(Reference Iizuka1). Because of their strong sweetness and low-calorie characteristics, artificial sweeteners were generally considered safe and highly appreciated by consumers for weight loss and glycaemic control(Reference Alharthi, Alaisayi and Alalawi2–Reference Norén and Forssell4).
RIG-I and MDA5 cooperatively recognize the DENV replicative-form dsRNA to activate innate immunity
Abstract RIG-I like receptors (RLRs) are a family of cytosolic RNA sensors that sense RNA virus infection to activate innate immune response. It is generally believed that different RNA viruses are recognized by either RIG-I or MDA5, two important RLR members, depending on the nature of pathogen-associated molecular patterns (PAMPs) that are generated during RNA virus infection.
Discovery of ZLC491 as a Potent, Selective, and Orally Bioavailable CDK12/13 PROTAC Degrader
Introduction Click to copy section linkSection link copied! Cyclin-dependent kinases (CDKs) are evolutionarily conserved serine/threonine protein kinases that regulate cell cycle progression and gene transcription by interacting with their corresponding cyclins. (1) CDK12 and its paralog CDK13 are transcription-associated CDKs with cyclin K (CCNK) as the partner protein.
Domestic vs. Foreign Institutional Investors: Who Improves ESG and Value of Chinese Companies?
1. Introduction Unlike advanced capital markets, where institutional investors account for over 90% of market capitalization, China’s stock market has a high proportion of individual investors, which may hinder the efficient procurement and utilization of resources.
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