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Yuan Yin on Muck Rack

Yuan Yin

As seen in: Color Research & Application, Nature, Wiley Online Library, arXiv, Frontiers, Gut Journal, MDPI, Taylor & Francis Online, ACS Publications, Journal of Biomedical Science and
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Articles

Sintilimab plus Bevacizumab biosimilar IBI305 and chemotherapy as a first-line treatment in advanced gastric or gastroesophageal junction adenocarcinoma (SBAGA): a single-arm, phase Ib/II study

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By Mo Cheng, Pengfei Zhang, Qiancheng Hu, Jitao Zhou, Ruihong Dai, Wenke Li, Jing Wei, Menghui Xu, Yanna Lei, Xiaoying Li, Xiufeng Zheng, Qian Huang, Zhiping Li, Bo Zhang, Wen Zhuang, Zhixin Chen, Xiaolong Chen, Chaoyong Shen, Weihan Zhang, Kai Liu, Linyong Zhao, Xiaonan Yin, Zhaolun Cai, Yuan Yin, Ji Chen, Chunjuan Liu, Deying Kang, Mojin Wang, Hongfeng Gou, Kun Yang, Jiankun Hu, Feng Bi, Ming Liu Verified, Boqiang Peng
| Nature Verified
Abstract Adding anti-PD-1 or anti-VEGF therapy to chemotherapy improves survival in patients with advanced gastric cancer, yet outcomes remain poor. This Phase Ib/II trial aimed to evaluate the efficacy and safety of combining sintilimab, the bevacizumab biosimilar IBI305, and CapeOX chemotherapy as a first-line treatment for patients with HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma (GA/GEJA).
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Human-in-the-Loop co-Design

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By Yuan Yin, Haoyu Zuo, Ji Hye Han
| Taylor & Francis Online
Abstract This study aims to enhance understanding of the performance of human-learning HITL approaches in human-AI co-design processes. The conversation mode of human-learning HITL in human-AI co-design processes and usage patterns performance in AI-learning HITL were explored. Subsequently, the effects of the two different HITL approaches on human-AI co-design processes were investigated.
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SIRT7-mediated ACSL3 delactylation suppresses colorectal cancer progression by orchestrating tumor-associated macrophage ferroptosis and polarization

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By Chaoqun Li, Peng Teng, Yan Qin, Junhui Tang, Xiaohui Hu, Yuna Li, Feiyu Qin, Surui Yao, Xiaowei Qi, Zhaohui Huang, Yuan Yin, Lingzhen Jiang
| Nature Verified
Abstract Dysregulated metabolism and functions of immune cells in the tumor microenvironment (TME) are key factors contributing to cancer progression. As the core immune cells in TME, tumor-associated macrophages (TAMs) have become a central focus in metabolic research of TME, though underlying mechanisms are not fully elucidated. Here, we found that long-chain acyl-coenzyme A synthetase-3 (ACSL3) is highly expressed in TAMs and correlates with poor prognosis in colorectal cancer (CRC).
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