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AI-assisted telerehabilitation in early Parkinson’s disease: a multicenter, randomized, multi-arm comparative trial
Abstract This exploratory, multicenter, randomized, rater-blinded, multi-arm comparative trial aimed to evaluate the feasibility and exploratory clinical signals of an AI-facilitated telerehabilitation system across different intervention durations in early-stage Parkinson’s disease (PD). One-hundred and twenty PD patients (Hoehn-Yahr stage ≤2.5) were randomized in a 1:1:1 ratio into short-term (1 month), medium-term (2 months), and long-term (3 months) training groups (15–30 min, 5 days/week).
The histone deacetylase BpHST1 influences branch angle in white birch ( Betula platyphylla )
INTRODUCTION Plant architecture, defined by the integrated manifestation of traits, such as plant height, branch number, and branch angle, directly governs productivity (Hollender & Dardick, 2014; Su et al., 2023). The optimization of canopy architecture is therefore a promising strategy for enhancing yield (Xia et al., 2021).
Sphingosine kinase-2 inhibition promotes immunogenic differentiation of myeloid-derived suppressor cells through an Acetyl-CoA carboxylase-phosphatidylcholine axis
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Abstract Myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME) limit the efficacy of adoptive T cell therapies, highlighting the need to overcome tumor-associated immunosuppression. Sphingosine-1-phosphate (S1P), is an abundant signaling lipid in the TME.
By PARAMITA CHAKRABORTY, Shilpak Chatterjee, Mohamed Faisal Kassir, Seungho Choi, Natalia Oleinik, Özge Saatci, Satyajit Das, Anupam Gautam, Stephanie Mills, Reid DeMass, Yueying Liu, Rasesh Y. Parikh, Sandip Paul, Souvik Seal, Charles Smith, Michael Lilly, Vamsi K. Gangaraju, Yuri K. Peterson, Elizabeth Hill, Ozgur Sahin, Norbert Leitinger, Paulo C. Rodriguez, Besim Ogretmen, Shikhar Mehrotra Verified, Wyatt Wofford, Odai Darawshi, Nathaniel Oberhoeltzer, Zacharia Hedley, Meenal Mehrotra
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Nature
Verified
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