Yuying Huang
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BRAF recruitment to spinal sensory synapses promotes neuropathic pain by potentiating transsynaptic NMDA receptor activity
Editor’s summary Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Editor’s summary Increased activity of glutamate receptors called NMDARs in the spinal cord drives chronic neuropathic pain. Jin et al.
Sensory neuron BRAF mediates opioid-induced hyperalgesia and tolerance via presynaptic NMDA receptor hyperactivity
ResearchNeuroscienceOncology Open Access | 10.1172/JCI201808 J Clin Invest. https://doi.org/10.1172/JCI201808. Copyright © 2026, Jin et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Opioids are essential analgesics for managing severe pain but can paradoxically increase pain sensitivity (hyperalgesia) and diminish analgesic efficacy (tolerance).
Fully Bayesian Sequential Design for Heteroscedastic Stochastic Simulations
Advanced search Technometrics Latest Articles Submit an article Journal homepage Full Article Figures & data References Supplemental Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/00401706.2026.2703239?needAccess=true Accepted author version Abstract We present a fully Bayesian sequential strategy for predicting the mean response surface of heteroscedastic stochastic simulation models.
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