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Zaijun Ma

As seen in: Cell Press
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Articles by Zaijun Ma

Mesenchymal drift: A convergent framework for the hallmarks of aging

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By Jinlong Y. Lu, William B. Tu, Shuai Ma, Zaijun Ma, Ivan Imaz-Rosshandler, Mingxi Weng, Jing Qu, Concepcion Rodriguez Esteban, Pradeep Reddy, Guang-Hui Liu
| Cell Press Verified
Keywords aging epithelial-to-mesenchymal transition endothelial-to-mesenchymal transition rejuvenation biomarkers partial reprogramming Yamanaka factors fibrosis cellular identity and plasticity geroscience Introduction Aging biology is commonly framed through a set of canonical “hallmarks.” Since their original formulation,1 these hallmarks have expanded from nine to twelve2 and more recently to fourteen,3 reflecting both the growing complexity of aging biology and the field’s effort to...
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Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila

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By Hui Wang, Han Wang, Xiaofen Wu, Huanhuan Ma, Yun Yang, Feng Liu, Zhandong Liu, Rui Liu, Nan Liu, Zaijun Ma, Yuping Cai, Kongyan Niu, Wenhua Tong, Yaoyang Zhang, Zheng-Jiang Zhu
| eLife
Abstract Epigenetic alteration has been implicated in aging. However, the mechanism by which epigenetic change impacts aging remains to be understood. H3K27me3, a highly conserved histone modification signifying transcriptional repression, is marked and maintained by Polycomb Repressive Complexes (PRCs). Here, we explore the mechanism by which age-modulated increase of H3K27me3 impacts adult lifespan.
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