Zaolan Liang on Muck Rack

Zaolan Liang

As seen in: Nature
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Articles

Birth imprinting effects on the antibody responses of H7N9 patients from 2013-2018 in China

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By Xia LIN, Liping Chen, Yin Su, Zaolan Liang, Cheng Xiao, Yaqin Bai, Hui Lei, Fangmei Lin, Zhenting Huang, Bingyi Yang, Tim K. Tsang, Nisha Bhandari, Raghavan Varadarajan, Malik Peiris, Benjamin J Cowling, Tang Li, Maureen A. McGargill, Paul Thomas, Nanshan Zhong, Richard Webby, Zifeng Yang, Mark P Zanin, Sook-San Wong, Wenda Guan, Yunceng Weng
| Nature Verified
Abstract There is an urgent need to understand the immune correlates of protection against avian influenza viruses (AIV), where pre-existing immunity may be limited. Here, we characterized the antibody response in 12 severely ill A(H7N9) patients and examined its association with early-life imprinting and clinical outcome. We find that A(H7N9) patients imprinted with A(H2N2) during early life show minimal H7-IgM and a rapid IgG response across diverse hemagglutinin subtypes.
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A(H2N2) and A(H3N2) influenza pandemics elicited durable cross-reactive and protective antibodies against avian N2 neuraminidases - Nature Communications

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By Kimberly Edwards, Wenjun Song, Huachen Zhu, Nisha Bhandari, Raghavan Varadarajan, Malik Peiris, Vijaykrishna Dhanasekaran, Benjamin J Cowling, Richard Webby, Zaolan Liang
| Nature Verified
Abstract Human cases of avian influenza virus (AIV) infections are associated with an age-specific disease burden. As the influenza virus N2 neuraminidase (NA) gene was introduced from avian sources during the 1957 pandemic, we investigate the reactivity of N2 antibodies against A(H9N2) AIVs. Serosurvey of healthy individuals reveal the highest rates of AIV N2 antibodies in individuals aged ≥65 years.
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