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Aberrant activation of Wnt/?-catenin signalling contributes significantly to the development of human colorectal cancers and ?-catenin is the key signalling molecule transducing canonical Wnt/?-catenin signalling. Therefore, ?-catenin is a promising therapeutic target for cancer treatment. This study demonstrates that the oncogenic IKK? kinase phosphorylates ?-catenin to restrain its hyper activation, therefore promoting colorectal cancer (CRC) cell proliferation. IKK?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
