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Zenghong Li

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Articles

Multi-omics Mendelian randomization and experimental validation suggest MAPK3 as a potential drug target for knee osteoarthritis

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By Jinlei Li, Yongsheng Xu, Juan Xia, Hong Yin, Weitong Liu, Jingfan Yang, Guang Yang, Ying Deng, Ming Zhou, Yongjin Wei, Zenghong Li
| Nature Verified
Abstract Knee osteoarthritis (KOA) is a major cause of pain and disability, yet effective disease-modifying treatments remain limited. Endoplasmic reticulum stress contributes to joint degeneration, but genetically supported targets remain unclear. We integrated blood eQTL, plasma pQTL, and KOA GWAS data using Mendelian randomization and colocalization analyses.
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