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Zhanying Bi

As seen in: Nature, Cell Press
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Articles

Characterizing the metabolomes of microglia, astrocytes and neurons in ageing and Alzheimer’s brains

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By Jie Yu, Fengzhi Li, Xing-jun Chen, Chenye Mou, Di Yao, Zhanying Bi, Xiaoli Chen, Lulu Du, Ziyan Feng, Xinshuang Zhang, Xiaoqian Yu, Lauren G. Zacharias, Ralph J. DeBerardinis, Li Zhang, Zhen Li, Benyan Luo, Xiao-Ling Hu, Woo-ping Ge
| Nature Verified
Abstract Neurons and glia are distinct in their morphology, development and function, possessing unique transcriptomes and proteomes, but little is known about their metabolomes. The challenge of brain cell metabolic profiling is to obtain a large number of cells for reliable analysis. Here we purified microglia, astrocytes and neurons from mouse brains, identifying >70 metabolites through targeted metabolomics and 9,854 metabolite features via untargeted metabolomics.
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Comprehensive characterization of metabolic consumption and production by the human brain

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By Yilong Wang, Lebo Zhou, Nan Wang, Baoshan Qiu, Di Yao, Jie Yu, Yufeng Xie, Xiaoqian Yu, Xunming Ji, Zhen Li, Dapeng Mo, Woo-ping Ge, Miaoqing He, Zhanying Bi, Xiangli Sun
| Cell Press Verified
Keywords brain metabolism arteriovenous comparison cerebral venous stenosis cerebral venous thrombosis blood circulation metabolite lipid metabolomics uptake release Introduction The mammalian brain is characterized by its substantial energy demands and distinctive metabolic activities.
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