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Zhefang Wang

As seen in: Nature, Cell Reports Medicine
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Articles

Mitophagy in pancreatic cancer: mechanistic insights and implications for novel therapeutic strategies - Cell Death Discovery

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By Zhefang Wang
| Nature Verified
Abstract Pancreatic ductal adenocarcinoma (PDAC) presents significant treatment challenges, primarily due to its propensity for developing resistance to therapeutic interventions. While the underlying mechanisms remain elusive, they are closely associated with mitochondrial adaptation in response to treatment. Mitophagy, a selective subtype of autophagy that eliminates damaged or surplus mitochondria, is crucial for tumorigenesis, progression, and treatment resistance in cancers.
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DDX5 super-enhancer promotes vasculogenic mimicry formation and metastasis in nasopharyngeal carcinoma by enhancing ADAM10 transcription

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By Tian Xia, Haimeng Yin, Qingwen Zhu, Kaiwen Zhang, Haijing Xie, Ying Shan, Siyu Zhang, RUI ZHU, Mengyu Miao, Yingna Lu, Jianmei Zhao, Zhefang Wang, Yiwen You
| Cell Reports Medicine Verified
Immunohistochemistry and PAS staining Mouse orthotopic xenografts were pretreated with a decalcifying solution, following which the tumor tissues from the patients with nasopharyngeal carcinoma and mouse subcutaneous and orthotopic xenografts were fixed with 1% paraformaldehyde and embedded in paraffin. The tumor sections were dewaxed and rehydrated.
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