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Articles by Zhen Ge
JYP0322, a highly selective and brain-penetrant ROS1 inhibitor, overcomes ROS1 G2032R resistance mutation in NSCLC: The first-in-human phase 1 trial
Keywords ROS1 inhibitor brain metastases G2032R mutation tyrosine kinase inhibitor phase 1 trial Introduction ROS1, encoded by the proto-oncogene ROS1, is a receptor tyrosine kinase that drives tumorigenesis through chromosomal re-arrangements.1,2 These genetic events result in fusion of the ROS1 tyrosine kinase domain with partner genes (e.g., CD74, EZR, SDC4, SLC34A2), leading to constitutive kinase activations.3,4 ROS1 fusions occur in approximately 1%–2% of non-small cell lung cancer...
LINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma
Abstract Ferroptosis is a form of iron-dependent programmed cell death (PCD) that, once activated, inhibits tumor progression. However, the specific mechanisms influencing ferroptosis in nasopharyngeal carcinoma (NPC) are limited and warrant further investigation. This study proposes that MICAL2 not only influences the nuclear translocation of p53 but also facilitates the ubiquitination of p53 by recruiting the E3 ubiquitination ligase MDM2, leading to its degradation.
Comparison between sub-lobar resection and lobar resection for clinical stage IA (tumor size ≤ 2 cm) lung invasive mucinous adenocarcinoma with tumor spread through air spaces: A multi-center real-world study
Keywords Lung invasive mucinous adenocarcinoma Spread through air spaces Sub-lobar resection Lobar resection Overall survival Abbreviations ADC (adenocarcinoma) AT (adjuvant therapy) BMI (body mass index) CI (confidence interval) CT (computed tomography) DLCO (diffusing capacity for carbon monoxide) EBUS-TBNA (endobronchial ultrasound-guided trans-bronchial needle aspiration) FEV1 (forced expiratory volume in 1s) HR (hazard ratio) IMA (lung invasive mucinous adenocarcinoma) IQR (interquartile...
Coupling Photocatalytic Reduction and Biosynthesis towards Sustainable CO2 Upcycling
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Electrostatic Force‐Tailored PEO‐Based Solid Electrolyte with Fast Li+ Transport for Ultra‐Robust Lithium Metal Batteries
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202419998-sup-0001-SuppMat.docx8.6 MB Supporting Information References 1, , , , , , , Adv. Mater. 2023, 35, 2206228. 2, , , , , , , , , , , , , , , Adv. Energy Mater. 2023, 13, 2300815. 3, , , , , Chem. Rev. 2020, 120, 6820. 4, , , , , , Adv. Energy Mater. 2023, 13, 2301746. 5a) , , , , J. Power Sources 1997, 68, 432; b) , , , , J. Power Sources 1995, 54, 393. 6, , , , , , , , Adv. Funct. Mater.
InfoPO: On mutual information maximization for large language model alignment
We study the post-training of large language models (LLMs) with human preference data. Recently, direct preference optimization and its variants have shown considerable promise in aligning language models, eliminating the need for reward models and online sampling. Despite these benefits, these methods rely on explicit assumptions about the Bradley-Terry (BT) model, which makes them prone to over-fitting and results in suboptimal performance, particularly on reasoning-heavy tasks.
Intravascular ultrasound-guided versus angiography-guided percutaneous coronary intervention in acute coronary syndromes (IVUS-ACS): a two-stage, multicentre, randomised trial
Summary Intravascular ultrasound-guided percutaneous coronary intervention has been shown to result in superior clinical outcomes compared with angiography-guided percutaneous coronary intervention. However, insufficient data are available concerning the advantages of intravascular ultrasound guidance for patients with an acute coronary syndrome.
Imidazolium‐based ionic thermoplastic polyurethane with low surface energy and antibacterial activities
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. REFERENCES 1, , , , Macromol. Rapid Commun. 2021, 42, 2100501. 2, , , , , J. Appl. Polym. Sci. 2022, 139, 52181. 3, , , , , , , , , RSC Adv. 2023, 13, 7020. 4, , , J. Mater. Sci. 2014, 49, 7339. 5, , J. Mater. Sci. 2020, 55, 73. 6, J. Macromol. Sci., Part A: Pure Appl. Chem 2021, 58, 579. 7, , , Macromol. Rapid Commun. 2021, 42, 2100391. 8, , , , , , Rev. Chem. Eng. 2019, 35, 445. 9, , , , Russ. J. Appl. Chem. 2021, 94, 647.
Designing Efficient Single-Atom Alloy Catalysts for Selective C═O Hydrogenation: A First-Principles, Active Learning and Microkinetic Study
RETURN TO ARTICLES ASAPPREVEnergy, Environmenta...Energy, Environmental, and Catalysis ApplicationsNEXT Haisong Feng State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R.
Effect of suture closure and staple closure on postoperative wound complications in patients undergoing knee replacement surgery: A meta‐analysis
1 INTRODUCTION Surgical site infection (SSI) remains an important issue following knee replacement operations. SSI, which have been described as post operative wound infections, are a frequent post operative complication in orthopaedics.1, 2 Although SSI tend to be just skin injuries, even if they look small, they can cause severe post-op complications.
Unlocking the Capacity of Bismuth Oxide by a Redox Mediator Strategy for High-Performance Aqueous Zn-Ion Batteries
RETURN TO ARTICLES ASAPPREVEnergy, Environmenta...Energy, Environmental, and Catalysis ApplicationsNEXT Nannan Liu School of Chemistry and Chemical Engineering, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, China , Zeping Liu School of Chemistry and Chemical Engineering, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, China , Jiyang Li Yangtze Dleta Institute (Huzhou),...
Prognostic impact of tumor spread through air spaces for T2aN0 stage IB non‐small cell lung cancer
4 DISCUSSION Surgical resection is the recommended form of treatment for lung cancer, which is the primary reason for cancer-related deaths globally.13 However, approximately 20%–40% of early-stage NSCLC patients relapsed after surgery.14 Multiple pathological factors influence prognosis, such as histological subtype, lymphatic invasion, vascular invasion, and pleural invasion. Recently, researchers have discovered that STAS affects the prognosis of lung cancer. In 2015, Kadota et al.
Tyrosinase Inhibitory Peptides from Enzyme Hydrolyzed Royal Jelly: Production, Separation, Identification and Docking Analysis
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Study on GAP Adhesive-Based Polymer Films, Energetic Polymer Composites and Application
Open AccessArticle by Siyuan Wu , Xiaomeng Li *, Zhen Ge and Yunjun Luo School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China * Author to whom correspondence should be addressed.
Mechanism of Extractive Separation of Light Cycle Oil Using a Deep Eutectic Solvent Composed of Tetrabutylphosphonium Bromide and Levulinic Acid
Download Hi-Res ImageDownload to MS-PowerPointCite This:Energy Fuels 2022, XXXX, XXX RETURN TO ARTICLES ASAPPREVFossil FuelsNEXT Zhen Ge Zhen Ge State Key Laboratory of Chemical Engineering, School of Chemical Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China , Hongye Cheng*, Guojin Zhang Guojin Zhang State Key Laboratory of Chemical Engineering, School of Chemical Engineering, East China University of Science and Technology, 130 Meilong...
Rationale and design for comparison of non-compliant balloon with drug-coating balloon angioplasty for side branch after provisional stenting for patients with true coronary bifurcation lesions: a prospective, multicentre and randomised DCB-BIF trial
http://orcid.org/0000-0001-7428-119XXiao-Fei Gao1, Zhen Ge1, http://orcid.org/0000-0002-6268-2954Jing Kan1, Xiang-Quan Kong1, Yan Wang2, Chun-Guang Qiu3, Damras Tresukosol4, Yu-Quan He5, Qiang Wu6, Ji-Fu Li7, Hai-Tao Yuan8, Chengxing Shen9, Xiang Chen2, Muhammad Munawar10, Bashir Hanif11, Teguh Santoso12, http://orcid.org/0000-0002-9169-6968Eun-Seok Shin13, Imad Sheiban14, Fei Ye1, Jun-Jie Zhang1, Shao-Liang Chen1 On behalf of the DCB-BIF investigators 1Department of Cardiology, Nanjing First...
Three-Year Outcomes of the ULTIMATE Trial Comparing Intravascular Ultrasound Versus Angiography-Guided Drug-Eluting Stent Implantation
JACC: Cardiovascular Interventions Xiao-Fei Gao, Zhen Ge, Xiang-Quan Kong, Jing Kan, Leng Han, Shu Lu, Nai-Liang Tian, Song Lin, Qing-Hua Lu, Xiao-Yan Wang, Qi-Hua Li, Zhi-Zhong Liu, Yan Chen, Xue-Song Qian, Juan Wang, Da-Yang Chai, Chong-Hao Chen, Tao Pan, Fei Ye, Jun-Jie Zhang, Shao-Liang Chen and for the ULTIMATE Investigators This article requires a subscription or purchase to view the full text.
3-Year Outcomes of the ULTIMATE Trial Comparing Intravascular Ultrasound Versus Angiography-Guided Drug-Eluting Stent Implantation:
Abstract Objectives The aim of this study was to explore the difference in target vessel failure (TVF) 3 years after intravascular ultrasound (IVUS) guidance versus angiographic guidance among all comers undergoing second-generation drug-eluting stent (DES) implantation.
Intravascular Ultrasound-Guided Versus Angiography-Guided Implantation of Drug-Eluting Stent in All-Comers: The ULTIMATE trial
Background Intravascular ultrasound (IVUS)-guided drug-eluting stent (DES) implantation is associated with less major adverse cardiovascular events (MACE) compared with angiography guidance for patients with individual lesion subset. However, the beneficiary effect on MACE outcome of IVUS guidance over angiography guidance in all-comers who undergo DES implantation still remains understudied.
Ultra-Broadband Wide-Angle Terahertz Absorption Properties of 3D Graphene Foam
As a next generation of detection technology, terahertz technology is very promising. In this work, a highly efficient terahertz wave absorber based on 3D graphene foam (3DG) is first reported. Excellent terahertz absorption property at frequency ranging from 0.1 to 1.2 THz is obtained owing to faint surface reflection and enormous internal absorption.
Enhanced thermoelectric performance through synergy of resonance levels and valence band convergence via Q/In (Q = Mg, Ag, Bi) co-doping
The temperature-dependent evolution of heavy-hole valence band contribution to the Seebeck coefficients of SnTe-based thermoelectric materials is revealed in situ by neutron and synchrotron powder diffraction. The additional carriers with high effective mass are created in a heavy-hole valence band above 493 K, which contribute to the electrical transport, and lead to a significant enhancement of the Seebeck coefficient at high temperature.
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