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Zhinan Yin on Muck Rack

Zhinan Yin

As seen in: Color Research & Application, Nature, Molecular Cancer, Cell Reports, Canadian Journal of Infectious Diseases & Medical Microbiology
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Articles

IL-17A-producing γδ T cells control pulmonary Mycobacterium abscessus infection in mice

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By Xiaoqian Hu, Haoye Liu, Zhijie Qin, Zhihao Wu, Yaqi Wan, Shuai Ma, Xuguang Yang, Zhinan Yin, Yiwei Chu, Wenhong Zhang, Lingyun Shao, Yuli Lin, Siran Lin, Wenchang Meng
| Nature Verified
Abstract The specific role of γδ T cells in non-tuberculous mycobacteria (NTM) infections remains incompletely understood. Here we characterized the immune landscape of pulmonary tissues from a Mycobacterium abscessus-infected NTM mice model. Interleukin-17 (IL-17)A+ γδ T cells were essential for controlling M. abscessus infection by directly eliminating extracellular bacteria.
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Metformin sensitizes esophageal squamous cell carcinoma to Vγ9Vδ2 T cell-mediated cytotoxicity by upregulating BTN3A1 and BTN2A1

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By Zishan Yang, Yadi Liu, Yixuan Han, Lijun Tan, Suli Wang, Shenglan Zhang, Chenyang Li, Yaxin Zhang, Zhinan Yin, Jian Li, Feng Ren, Piaoyi He, Yilong Ji
| Nature Verified
Abstact Metformin, a first-line anti-diabetic agent, exhibits broad-spectrum antitumor properties, though its underlying immunomodulatory mechanisms remain incompletely characterized. Here, we demonstrate that metformin significantly upregulates BTN3A1 and BTN2A1 expression on esophageal cancer cells in an AMPK-dependent manner, thereby sensitizing them to Vγ9Vδ2 T cell-mediated cytotoxicity.
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Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease - Signal Transduction and Targeted Therapy

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By Zhinan Yin, Le Li
| Nature Verified
Abstract The immunological synapse (IS) serves as the fundamental architectural framework for direct interactions and secretory crosstalk between immune cells, as well as between immune cells and other cells. Its dysregulation is thought to be a key underlying cause of immune evasion or inflammation observed in various diseases, including tumors and infections.
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