Zibai Lyu on Muck Rack

Zibai Lyu

As seen in: Cell Press, Cell Reports Medicine
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Articles

Multimodal targeting of metastatic renal cell carcinoma via CD70-directed allogeneic CAR-NKT cells

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By Yan-Ruide Li, Junhui Hu, Zhe Li, Enbo Zhu, Yuning Chen, Tyler Halladay, Xinyuan Shen, Ying Fang, Yichen Zhu, Zibai Lyu, Yanxin Tian, Jie Huang, Catherine Zhang, Yongpeng Xie, Hanwei Zhang, Tzung Hsiai, Arnold I. Chin, Lily Wu, Lili Yang, Annabel S. Zhao, Nathan Y. Ma
| Cell Reports Medicine Verified
Keywords Renal cell carcinoma RCC CD70 invariant natural killer T cell NKT cell CAR-NKT cell hematopoietic stem and progenitor cell HSPC tumor microenvironment TME alloreactive T cell allorejection patient-derived xenograft model PDX multimodal targeting Introduction Renal cell carcinoma (RCC), originating from renal epithelium, is the most prevalent type of kidney cancer, accounting for over 90% of all cases.1 RCC exhibits marked resistance to conventional chemotherapy and radiotherapy,...
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Advancements in CRISPR screens for the development of cancer immunotherapy strategies

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By Yan-Ruide Li, Yanxin Tian, Ying Fang, Zibai Lyu
| Cell Press Verified
CRISPR screen technology enables systematic and scalable interrogation of gene function by using the CRISPR-Cas9 system to perturb gene expression. In the field of cancer immunotherapy, this technology has empowered the discovery of genes, biomarkers, and pathways that regulate tumor development and progression, immune reactivity, and the effectiveness of immunotherapeutic interventions.
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