Despite a healthy diet, exercise, and a lot of sleep, stress, anxiety, and hormonal changes can leave our skin feeling a little lackluster or dull. Collagen loss is one of the side effects of aging, and can cause the skin to appear hollow and tired. That's where face masks with collagen come in handy. According to Dr. Rachel Nazarian, MD, there is no evidence that applying collagen topically to skin will stimulate collagen under the skin or help with anti-aging.