Abdullah Osman on Muck Rack

Abdullah Osman

  • Editor, Cinema Solace
As seen in: Nature, emerald insight, Texas Medical Center
occasional writer. 🇵🇸
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Articles

Acquired resistance in cancer: towards targeted therapeutic strategies - Nature Reviews Cancer

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By Alice Soragni, Erik S. Knudsen, Thomas N. O’Connor, Cristina E. Tognon, Jeffrey W. Tyner, Beatrice Gini, Donghwa Kim, Trever G. Bivona, Xingxing Zang, Agnieszka K. Witkiewicz, David Goodrich, Dadi Jiang, Seth T Gammon, Christopher D. Willey, Paul Boutros, Vlad C. Sandulache, Abdullah Osman, Jeffrey Myers, Kamiya Mehla, Pankaj K. Singh, Keith Chan, Hongbo Gao, Himangi G. Marathe
| Nature Verified
Abstract Development of acquired therapeutic resistance limits the efficacy of cancer treatments and accounts for therapeutic failure in most patients. How resistance arises, varies across cancer types and differs depending on therapeutic modalities is incompletely understood. Novel strategies that address and overcome the various and complex resistance mechanisms necessitate a deep understanding of the underlying dynamics.
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Evolution of Cisplatin Resistance Through Coordinated Metabolic Reprogramming of the Cellular Reductive State

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By Wangie Yu, Yunyun Chen, Nagireddy Putluri, Abdullah Osman
| Texas Medical Center
BACKGROUND: Cisplatin (CDDP) is a mainstay treatment for advanced head and neck squamous cell carcinomas (HNSCC) despite a high frequency of innate and acquired resistance. We hypothesised that tumours acquire CDDP resistance through an enhanced reductive state dependent on metabolic rewiring.
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