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Paul Boutros

As seen in: Nature, JAMA Oncology, Barron's, Cell Press, Cell Reports Medicine, DEV Community, Robb Report, HemOnc Today, Hodinkee, medRxiv and
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Articles

Advancing precision health discovery in a genetically diverse health system

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By Roni Malishkevich Haas, Michael Margolis, Angela Wei, Takafumi N. Yamaguchi, Jeffrey Feng, Thai Tran, Veronica Tozzo, Katelyn J. Queen, Vishakha Patil, Michael E. Broudy, Paul Tung, Shafiul Alam, Danielle Martinez, Yash Patel, Christa Caggiano, Nicole Zeltser, Rupert Hugh-White, Jaron Arbet, Ruhollah Shemirani, Mao Tian, Prapti Thapaliya, Lora Eloyan, Lawrence O. Chen, Sandra Lapinska, Maryam Ariannejad, Clara M Lajonchere, Eimear E. Kenny, Bogdan Pasaniuc, Alex Bui, Valerie Arboleda, Timothy S. Chang, Noah Zaitlen, Paul T. Spellman, Paul Boutros, Daniel H Geschwind
| Cell Press Verified
Keywords health-system biobank electronic health records genomic medicine genetic association ancestry GLP-1 receptor agonists semaglutide phenome-wide association study exome-wide association study polygenic scores Introduction The integration of electronic health records (EHRs) with genetic data is transforming biomedical research, offering unprecedented opportunities for preventing and managing common medical conditions.1 Longitudinal sampling, linked with genetic and environmental data,...
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Author Correction: Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial - Nature Medicine

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By Farshad Nassiri, Olivia Singh, Timothy F. Cloughesy, Kenneth Aldape, Marta Alonso Verified, Paul Boutros, Roger Stupp, Candelaria Gomez-Manzano, Frederick F. Lang
| Nature Verified
Correction to: Nature Medicine https://doi.org/10.1038/s41591-023-02347-y, published online 15 May 2023. In the version of the article initially published, in the “TME-high” row in Extended Data Fig. 6a, the images for “CD3” and “CD8” were identical. Extended Data Fig. 6a has now been amended with the correct image for “CD8” in the HTML and PDF versions of the article.
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Extracellular vesicle heterogeneity through the lens of multiomics

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By Taylon F Silva, Elizabeth Hutchins, Wenyan Zhao, Yari Ciani, Minhyung Kim, Emily R. Ko, Javier Mariscal, Zhuyu Qiu, Ágnes Kittel, Bo Zhou, Yang Wang, Megan Hall, Rebecca Reiman, Michael Freeman, Sarah Parker, Jennifer Van Eyk, Wei Yang, Edwin M. Posadas, Jlenia Guarnerio, John Nolan, Clotilde Théry, Andries Zijlstra, Shannon Stott, Sungyong You, Francesca Demichelis, Paul Boutros, Kendall Van Keuren-Jensen, Dolores Di Vizio, Fatima Bedier, Francesca Galasso
| Cell Reports Medicine Verified
Results For this study, we followed the guidelines from the International Society for Extracellular Vesicles.25 We adapted a protocol, previously applied to human primary dendritic cells, which are benign cells, to isolate L-EVs from S-EVs15 from cancer cells. The protocol employs differential ultracentrifugation (dUC) to pellet EVs according to their size and density, followed by flotation on a discontinuous iodixanol gradient.
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