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Adele G. Lopes

As seen in: Nature
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Articles by Adele G. Lopes

Aneuploidy selects for the acquisition of driver genes in breast cancer

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By Khalid N Al-Zahrani, Jocelyn Nurtanto, Andreea Obersterescu, Katie Teng, Christopher Lowden, Lauren Caldwell, Miguel A. Pérez-Castro, Ricky Tsai, Alexander T Bahcheli, Shifei Wu, Masahiro Narimatsu, Iosifina Fotiadou, Kin Chuah Chan, Linkang Zhang, K. W. Annie Bang, Michael Parsons, Larissa Mourao, Palavalasa Sravya, Li Zhang, Peter Sajjakulnukit, Costas A. Lyssiotis, Alexander D. Borowsky, Colinda L. G. J. Scheele, Daniel Wahl, Hartland W. Jackson, Katherine Stewart, Elaine Fuchs, Sean Egan, Miguel Angel Pujana, Jüri Reimand, Jeffrey L. Wrana, Daniel Schramek, Ellen R. Langille, Julien Dessapt, Cynthia H. Chiu, Geraldine Mbamalu, Adele G. Lopes, E. Idil Temel, Liddy McCulla
| Nature Verified
Abstract Chromosome instability is highly prevalent in cancer and drives large-scale chromosomal imbalances, known as aneuploidies1,2,3,4. How aneuploidy contributes to tumorigenesis remains difficult to study due to the vast numbers of genes affected. Here we established a CRISPR knockout- and activation-linked assay (CRISPR-KOALA), enabling high-throughput bidirectional genetic screens in immunocompetent mouse models of cancer.
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