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Palavalasa Sravya

As seen in: Nature, Cell Metabolism
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Articles

Aneuploidy selects for the acquisition of driver genes in breast cancer

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By Khalid N Al-Zahrani, Jocelyn Nurtanto, Andreea Obersterescu, Katie Teng, Christopher Lowden, Lauren Caldwell, Miguel A. Pérez-Castro, Ricky Tsai, Alexander T Bahcheli, Shifei Wu, Masahiro Narimatsu, Iosifina Fotiadou, Kin Chuah Chan, Linkang Zhang, K. W. Annie Bang, Michael Parsons, Larissa Mourao, Palavalasa Sravya, Li Zhang, Peter Sajjakulnukit, Costas A. Lyssiotis, Alexander D. Borowsky, Colinda L. G. J. Scheele, Daniel Wahl, Hartland W. Jackson, Katherine Stewart, Elaine Fuchs, Sean Egan, Miguel Angel Pujana, Jüri Reimand, Jeffrey L. Wrana, Daniel Schramek, Ellen R. Langille, Julien Dessapt, Cynthia H. Chiu, Geraldine Mbamalu, Adele G. Lopes, E. Idil Temel, Liddy McCulla
| Nature Verified
Abstract Chromosome instability is highly prevalent in cancer and drives large-scale chromosomal imbalances, known as aneuploidies1,2,3,4. How aneuploidy contributes to tumorigenesis remains difficult to study due to the vast numbers of genes affected. Here we established a CRISPR knockout- and activation-linked assay (CRISPR-KOALA), enabling high-throughput bidirectional genetic screens in immunocompetent mouse models of cancer.
Open in Who Shared Issue with article?

GABA signaling activation drives glioblastoma progression in female mice through myeloid-derived suppressor cells

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By Asmita Pathak, Palavalasa Sravya, Bruno Colon, Yadi Zhou, Brandon Leon, Jonathan Mitchell, Beatriz Mateo-Victoriano, Andrew Scott, Harrison Wong, Li Zhang, Juyeun Lee, Kristen E. Kay, Efe Karaca, Diana H. Chin, Haleh Amirian, Irem Karaman, Katelyn Sellick, Danielle Dean, Daniel Cortes, Jashodeep Datta, Scott M. Welford, Maria Franco, Kiran Kurmi, Ashish Shah, Feixiong Cheng, Justin D Lathia, Priyamvada Rai, David B. Lombard, Costas A. Lyssiotis, Dionysios C. Watson, Michele Ceccarelli, Daniel Wahl, Defne Bayik, Erika Ciervo, Oriana Y. Teran Pumar, Durga Prasad Gannamedi, Preyasha Shrestha
| Nature Verified
Abstract Sex differences in immune responses impact cancer outcomes and treatment response, including in glioblastoma (GBM). However, host factors underlying distinct immune-cancer interactions are poorly understood. Here we identify γ-aminobutyric acid (GABA) as a female-specific driver of GBM-promoting immune response.
Open in Who Shared Issue with article?

Digital twins for in vivo metabolic flux estimations in patients with brain cancer

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By Baharan Meghdadi, Wajd N Al-Holou, Andrew Scott, Anjali Mittal, Ningning Liang, Abhinav Achreja, Alexandra O’Brien, Kathy Do, Zhe Wu, Nathan Qi, Vijay Tarnal, Sriram Venneti, C. Ryan Miller, Jann N. Sarkaria, Weihua Zhou, Theodore Lawrence, Costas A. Lyssiotis, Daniel Wahl, Deepak Nagrath, Palavalasa Sravya, Jiane Feng, Andrew J Scott, Palavalasa Sravya
| Cell Metabolism Verified
Results We introduce a digital twin approach that leverages scRNA-seq and in vivo 13C-enrichment data from patients with brain cancer9 (Figure 1A) and employs flux balance analysis (FBA) and INST-MFA to generate thousands of patient fluxes and nearly 1 million time-dependent isotopologue profiles (Figure 1B).
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