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Aijia Wen

As seen in: Nature, BioRxiv
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Articles

Conformational hijacking of lipoprotein transporter LolDF enables precision antimicrobial activity against Acinetobacter baumannii

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By Jie Pang, Yawen Chen Verified, Dengcheng Zhou, Lijue Wang, Yuling Xiao, Zhibo Zhang, Zhaxi Zerang, Lele Zhang, Xiang Gu, Min Xiao, Jingyu Wang, Hui Cui, Aijia Wen, Shouyue Zhang, Yiwen Zhang, Binwu Ying, Liang Ouyang, Xiawei Wei, Bi-Sen Ding, Xiaodi Tang, Haohao Dong, Maolin Duan
| Nature Verified
Abstract Acinetobacter baumannii is a critical-priority pathogen with increasing antibiotic resistance. Here, we define the mechanism of abaucin, a first-in-class narrow-spectrum antibiotic that selectively targets A. baumannii by inhibiting its essential lipoprotein transporter, LolDF. Extending prior studies of archived strains, we demonstrate potent activity against clinically isolated carbapenem-resistant A. baumannii (CRAB) strains both in vitro and in a murine pneumonia model.
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Structural insights into transcription regulation of the global virulence factor PhoP from Mycobacterium tuberculosis

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By Jing Shi, Qian Song, Zhenzhen Feng, Aijia Wen
| BioRxiv
Abstract Mycobacterium tuberculosis (Mtb), remaining as the leading cause of the worldwide threat Tuberculosis, relies heavily on its transcriptional reprogramming of diverse stress genes to swiftly adapt to adverse environments and ensure infections. The global virulence factor PhoP plays a pivotal role in coordinating transcription activation or repression of the essential phosphate-nitrogen metabolic remodeling genes.
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