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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Articles
Trans-Eurasian steppe herder and barley farmer migrations shaped paternal genomic dynamics in Northwest China and Hui evolution
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Human populations across Eurasia have long been connected through the steppe corridor and Silk Road, yet their paternal genetic history remains poorly understood.
Mechanistic basis of LolDF-mediated lipoprotein transport in Acinetobacter
Abstract Lipoprotein trafficking is essential for Gram-negative bacteria to maintain the outer membrane, a permeability barrier critical for survival and antibiotic resistance. While most bacteria employ the canonical LolCDE transporter, Acinetobacter utilizes a noncanonical LolDF system whose mechanism has remained unclear. Here we determine cryo-EM structures of Acinetobacter baylyi LolDF in substrate-bound, AMP-PNP-bound, and LolA-bound states.
Mechanistic insights into TAM-mediated OMP assembly in Gram-negative bacteria
Keywords gram-negative bacteria TAM outer membrane biogenesis β-barrel protein assembly substrate translocation conformational dynamics cryo-electron microscopy Research topic(s) CP: microbiology Introduction Outer-membrane β-barrel proteins (OMPs) are essential for the physiology and the virulence of Gram-negative bacteria.1 They perform diverse and critical functions, including maintaining envelope integrity, mediating nutrient uptake and efflux, scaffolding for secretion and adhesion, and...
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