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Binwu Ying on Muck Rack

Binwu Ying

As seen in: Nature, Wiley Online Library, ScienceDirect, Frontiers, MDPI, Royal Society of Chemistry, Cell Reports, Canadian Journal of Infectious Diseases & Medical Microbiology
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Articles

Mechanistic basis of LolDF-mediated lipoprotein transport in Acinetobacter

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By Jie Pang, Yawen Chen Verified, Wen Qiao, Zijing Ju, Xiayu Zhu, Shenghai Chang, Lijue Wang, Zhibo Zhang, Zhaxi Zerang, Shuxian Xu, Yujiao Chen, Changshu Li, Binwu Ying, Bi-Sen Ding, Hao Chen, Shouyue Zhang, Xiawei Wei, Xiaodi Tang, Haohao Dong
| Nature Verified
Abstract Lipoprotein trafficking is essential for Gram-negative bacteria to maintain the outer membrane, a permeability barrier critical for survival and antibiotic resistance. While most bacteria employ the canonical LolCDE transporter, Acinetobacter utilizes a noncanonical LolDF system whose mechanism has remained unclear. Here we determine cryo-EM structures of Acinetobacter baylyi LolDF in substrate-bound, AMP-PNP-bound, and LolA-bound states.
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Mechanistic insights into TAM-mediated OMP assembly in Gram-negative bacteria

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By Qinghua Luo, Zhaxi Zerang, Yujiao Chen, Xiayu Zhu, Lili Yang, Zhibo Zhang, Hao Chen, Binwu Ying, Shenghai Chang, Juan Zhou, Haohao Dong, Xiaodi Tang, Xintan Dong, Jierou Zhang, Xiangyangpeng Li
| Cell Reports Verified
Keywords gram-negative bacteria TAM outer membrane biogenesis β-barrel protein assembly substrate translocation conformational dynamics cryo-electron microscopy Research topic(s) CP: microbiology Introduction Outer-membrane β-barrel proteins (OMPs) are essential for the physiology and the virulence of Gram-negative bacteria.1 They perform diverse and critical functions, including maintaining envelope integrity, mediating nutrient uptake and efflux, scaffolding for secretion and adhesion, and...
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Conformational hijacking of lipoprotein transporter LolDF enables precision antimicrobial activity against Acinetobacter baumannii

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By Jie Pang, Yawen Chen Verified, Dengcheng Zhou, Lijue Wang, Yuling Xiao, Zhibo Zhang, Zhaxi Zerang, Lele Zhang, Xiang Gu, Min Xiao, Jingyu Wang, Hui Cui, Aijia Wen, Shouyue Zhang, Yiwen Zhang, Binwu Ying, Liang Ouyang, Xiawei Wei, Bi-Sen Ding, Xiaodi Tang, Haohao Dong, Maolin Duan
| Nature Verified
Abstract Acinetobacter baumannii is a critical-priority pathogen with increasing antibiotic resistance. Here, we define the mechanism of abaucin, a first-in-class narrow-spectrum antibiotic that selectively targets A. baumannii by inhibiting its essential lipoprotein transporter, LolDF. Extending prior studies of archived strains, we demonstrate potent activity against clinically isolated carbapenem-resistant A. baumannii (CRAB) strains both in vitro and in a murine pneumonia model.
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