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Dengcheng Zhou on Muck Rack

Dengcheng Zhou

As seen in: Nature, Frontiers
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Articles

Conformational hijacking of lipoprotein transporter LolDF enables precision antimicrobial activity against Acinetobacter baumannii

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By Jie Pang, Yawen Chen Verified, Dengcheng Zhou, Lijue Wang, Yuling Xiao, Zhibo Zhang, Zhaxi Zerang, Lele Zhang, Xiang Gu, Min Xiao, Jingyu Wang, Hui Cui, Aijia Wen, Shouyue Zhang, Yiwen Zhang, Binwu Ying, Liang Ouyang, Xiawei Wei, Bi-Sen Ding, Xiaodi Tang, Haohao Dong, Maolin Duan
| Nature Verified
Abstract Acinetobacter baumannii is a critical-priority pathogen with increasing antibiotic resistance. Here, we define the mechanism of abaucin, a first-in-class narrow-spectrum antibiotic that selectively targets A. baumannii by inhibiting its essential lipoprotein transporter, LolDF. Extending prior studies of archived strains, we demonstrate potent activity against clinically isolated carbapenem-resistant A. baumannii (CRAB) strains both in vitro and in a murine pneumonia model.
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Mimicking acute airway tissue damage using femtosecond laser nanosurgery in airway organoids

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By Chunheng Mo, Chiwei Xu, Dengcheng Zhou
| Frontiers
1 Introduction Due to its physiological function, the lung is constantly exposed to external, airborne hazards such as pollutants or viruses. While this can lead to acute irritation of the lung epithelial tissue, long-term or high-dosage exposures might induce chronic inflammatory conditions (Vernooy et al., 2002; Guo et al., 2018).
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