Aixiao Xu

Keywords neuroblastoma N-Myc transcriptional activation ZDHHC22 S-acylation chemoresistance Get full text access Log in, subscribe or purchase for full access. References 1. Qiu, B. ∙ Matthay, K.K. Advancing therapy for neuroblastoma Nat. Rev. Clin. Oncol. 2022; 19:515-533 2. Park, J.R. ∙ Kreissman, S.G. ∙ London, W.B. ... Effect of Tandem Autologous Stem Cell Transplant vs Single Transplant on Event-Free Survival in Patients With High-Risk Neuroblastoma: A Randomized Clinical Trial JAMA.

Ursolic acid (UA) is a food-plant-derived natural product which has good anticancer activities and low toxicity. However, the poor water solubility of UA limits its application in clinic. To address this issue, we developed a carrier-free nanodrug by self-assembly of UA. Here, we showed that UA nanoparticles (NPs) have a near-spherical shape with a diameter of ∼150 nm.