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Yinbing Tang

As seen in: Nature, Cell Press
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Articles

Core transcriptional regulatory circuitry identified from patient-derived tumor cells provides a specific vulnerability for rhabdomyosarcoma

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By Shuangai Liu, Ziqi He, Yinbing Tang, Min He, Lifeng Zhang, Weili Xu, Jinhu Wang, Ting Tao
| Nature Verified
Abstract Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and adolescents, with limited targeted treatment options. Core transcriptional regulatory circuitry (CRC) proteins play crucial roles in tumor cell identity and survival. Here, we established 15 patient-derived tumor cells (PDCs) from RMS specimens and found that these cells retained the expression of RMS hallmark and dependency genes, as well as the genetic mutations in primary tumors.
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Acyltransferase ZDHHC22 promotes N-Myc transcriptional activation to drive neuroblastoma progression and chemoresistance

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By Aixiao Xu, Jianhua Zhang, Bing Wu, Minghao Xu, Tianrui Wang, Chen Shao, Shaowei Bing, Yunpeng Huang, Yanru Yao, Jinhu Wang, Yinbing Tang, Ji Cao, Xuejing Shao, Qiaojun He, Meidan Ying
| Cell Press Verified
Keywords neuroblastoma N-Myc transcriptional activation ZDHHC22 S-acylation chemoresistance Get full text access Log in, subscribe or purchase for full access. References 1. Qiu, B. ∙ Matthay, K.K. Advancing therapy for neuroblastoma Nat. Rev. Clin. Oncol. 2022; 19:515-533 2. Park, J.R. ∙ Kreissman, S.G. ∙ London, W.B. ... Effect of Tandem Autologous Stem Cell Transplant vs Single Transplant on Event-Free Survival in Patients With High-Risk Neuroblastoma: A Randomized Clinical Trial JAMA.
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