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Meidan Ying

As seen in: Nature, Cell Press
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Articles

Acyltransferase ZDHHC22 promotes N-Myc transcriptional activation to drive neuroblastoma progression and chemoresistance

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By Aixiao Xu, Jianhua Zhang, Bing Wu, Minghao Xu, Tianrui Wang, Chen Shao, Shaowei Bing, Yunpeng Huang, Yanru Yao, Jinhu Wang, Yinbing Tang, Ji Cao, Xuejing Shao, Qiaojun He, Meidan Ying
| Cell Press Verified
Keywords neuroblastoma N-Myc transcriptional activation ZDHHC22 S-acylation chemoresistance Get full text access Log in, subscribe or purchase for full access. References 1. Qiu, B. ∙ Matthay, K.K. Advancing therapy for neuroblastoma Nat. Rev. Clin. Oncol. 2022; 19:515-533 2. Park, J.R. ∙ Kreissman, S.G. ∙ London, W.B. ... Effect of Tandem Autologous Stem Cell Transplant vs Single Transplant on Event-Free Survival in Patients With High-Risk Neuroblastoma: A Randomized Clinical Trial JAMA.
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Palmitic acid activates c-Myc via dual palmitoylation-dependent pathways to promote colon cancer - Cell Discovery

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By Wenxin Du, Jianing Zhang, Yuexin Wang, Minjun Li, Ji Cao, Qiaojun He, Xuejing Shao, Meidan Ying
| Nature Verified
Abstract c-Myc is broadly hyperactivated in colon cancer, yet the mechanisms sustaining its transcriptional activation remain elusive. Here we identify palmitic acid (PA) as a metabolite cue that activates c-Myc via dual palmitoylation-dependent pathways operating across tumor initiation and progression. In colitis models, PA-rich diets exacerbate inflammation and enrich MYC target programs without increasing Myc mRNA.
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Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy

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By Liguo Wang, Meidan Ying, Yu Rao, Xuejing Shao
| Nature Verified
Abstract The discovery of effective therapeutic treatments for cancer via cell differentiation instead of antiproliferation remains a great challenge. Cyclin-dependent kinase 2 (CDK2) inactivation, which overcomes the differentiation arrest of acute myeloid leukemia (AML) cells, may be a promising method for AML treatment. However, there is no available selective CDK2 inhibitor.
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