Akshay Bareja

Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Supporting Information Filename Description oby70293-sup-0001-FigureS1.tiffTIFF image, 18.2 MB Figure S1: Demographic profile of Gene expression subset. Distribution plots for sex (A); race (B); age (C); and baseline BMI (D).

Abstract Cysteine is a reactive amino acid central to the catalytic activities of many enzymes. It is also a common target of post-translational modifications (PTMs), such as palmitoylation. This long-chain acyl PTM can modify cysteine residues and induce changes in protein subcellular localization. We hypothesized that cysteine could also be modified by short-chain acyl groups, such as cysteine S-acetylation.

Highlights • Short-term caloric restriction (CR) drastically alters the liver-derived plasma proteome • Circulating plasminogen increases with CR, which is necessary for satellite cell expansion • During CR, plasminogen signals to the satellite cell via the plasminogen receptor Plg-RKT • Loss of Plg-RKT prevents CR-induced SC expansion and associated regenerative enhancements Summary An intriguing effect of short-term caloric restriction (CR) is the expansion of certain stem cell populations,...