Alban Ordureau

Abstract The detection and identification of intracranial tumours is limited by the lack of accurate biomarkers and requires invasive biopsy procedures. We investigated a machine perception liquid biopsy approach to detect and identify intracranial tumours from peripheral blood and to discover biomarkers responsible for the predictions.

Abstract HMGCS1 is an underexplored target for inhibitor development compared to other MVP enzymes, despite its unique features, such as a ligandable cysteine. Chemical tools for HMGCS1 are currently limited, with Hymeglusin as the primary inhibitor, although its selectivity has not been fully validated. Here, we report the development of a suite of chemical probes that allow us to evaluate the selectivity, efficacy, and stability of Hymeglusin.

Abstract Mitochondrial homeostasis is maintained through complex regulatory mechanisms, including the balance of mitochondrial dynamics involving fusion and fission processes. A central player in this regulation is the ubiquitin–proteasome system (UPS), which controls the degradation of pivotal mitochondrial proteins. In this study, we identified cullin–RING E3 ligase 2 (CRL2) and its substrate receptor, FEM1B, as critical regulators of mitochondrial dynamics.