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Alexander Kay

As seen in: Nature, Yahoo News UK, Aol, BMJ Global Health, Frontiers, MDPI, Genome Medicine, The Lancet, AOL UK, Pediatrics and
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Articles

Targeted next-generation sequencing implementation in Eswatini identifies rifampicin and bedaquiline resistance undetected by routine diagnostic testing

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By Debrah Vambe, Alexander Kay, Mangaliso Ziyane, Sein Sein Thi, Leonardo De Araujo, Viola Dreyer, Tanja Niemann Verified, Andrea Maurizio Cabibbe, Jennifer Furin, Lindokuhle Dlamini, Gugu Maphalala, Makhosazana Dlamini, Daniela Maria Cirillo, Anna M Mandalakas, Christoph Lange, Christian Utpatel, Sindisiwe Dlamini, Stefan Niemann Verified, Mdigo Thunzini, Busizwe Sibandze, Sijabu Masina, Tafadzwa Mazuruse, Thulani Jele, Bheki Mamba, Mbongeni Dube, Nomthandazo Lukhele, Sphiwe Ngwenya
| Nature Verified
Abstract In Eswatini, multidrug-resistant (MDR) Mycobacterium tuberculosis (Mtb) strains harbouring the rifampicin-resistance (RR) rpoB I491F mutation are missed by routine diagnostics, including GeneXpert MTB/RIF Ultra (Xpert Ultra), line probe assays (LPA), and mycobacterium growth indicator tube (MGIT) phenotypic drug susceptibility testing (pDST). To address this diagnostic gap, Eswatini introduced targeted next-generation sequencing (tNGS) in 2019.
Open in Who Shared Issue with article?

MacBook Won’t Turn On? Causes and Fixes (Step-by-Step Troubleshooting)

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By Alexander Kay
| The Mac Observer Verified
If your MacBook will not turn on, start with three quick fixes: use a known good charger and wall outlet, force a restart by holding the power button for about 10 seconds, and disconnect every accessory (USB hubs, drives, dongles, external displays). These steps solve a large share of “dead MacBook” cases because power, a frozen startup state, or a bad peripheral is often the real cause.
Open in Who Shared View Duplicates (2) Issue with article?

Why you should consider a Mac mini over a MacBook?

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By Alexander Kay
| The Mac Observer Verified
If your “laptop” mostly stays plugged into a monitor on your desk, I think a Mac mini is often the better choice. You get the same macOS experience, but you stop paying for a built-in screen, keyboard, trackpad, and battery that you barely use. My view is simple: if you already have a good monitor and accessories, the Mac mini turns your money into performance and stability instead of portable hardware you might not need.
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