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Alexander M. Barclay

As seen in: Nature, BioRxiv, Cell Press
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Articles

Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & Evolution

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By Christian Feregrino, Silvia Aldrovandi, Anna A. Monaco, Alessa Ringel, Ariadna Morales, Tobias Zehnder, Rose Yinghan Behncke, Juliane Glaser, Alexander M. Barclay, Guillaume Andrey, Bjørt K. Kragesteen, René Hägerling, Stefan A. Haas, Martin Vingron, Igor Ulitsky, Julio C. Hechavarría, Nicolas Fasel, Michael Hiller, Darío G. Lupiáñez, Stefan Mundlos
| Nature Verified
Abstract Bats are the only mammals capable of self-powered flight, an evolutionary innovation based on the transformation of forelimbs into wings. The bat wing is characterized by an extreme elongation of the second to fifth digits with a wing membrane called the chiropatagium connecting them. Here we investigated the developmental and cellular origin of this structure by comparing bat and mouse limbs using omics tools and single-cell analyses.
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Automated fibril structure calculations in Xplor-NIH

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By Alexander M. Barclay, Moses H. Milchberg, Marcus D. Tuttle, Christopher Dennis, Charles D. Schwieters, Chad M. Rienstra, Owen A. Warmuth
| Cell Press Verified
Keywords automated assignment automated structure calculation α-synuclein fibril PASD protofilament solid-state NMR strict-symmetry Xplor-NIH Parkinson disease Get full text access Log in, subscribe or purchase for full access. References 1. Spera, S. ∙ Bax, A. Empirical Correlation between Protein Backbone Conformation and C-Alpha and C-Beta C-13 Nuclear-Magnetic-Resonance Chemical-Shifts J. Am. Chem. Soc. 1991; 113:5490-5492 2. Cornilescu, G. ∙ Delaglio, F. ∙ Bax, A.
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Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue

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By Dhruva D. Dhavale, Alexander M. Barclay, Collin G. Borcik, Katherine Basore
| BioRxiv
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