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Rose Yinghan Behncke on Muck Rack

Rose Yinghan Behncke

As seen in: Nature, MDPI, The Journal of Clinical Investigation
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Articles

Insights into KIF11 pathogenesis in Microcephaly-Lymphedema-Chorioretinopathy syndrome from a lymphatic perspective

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By JCI Insight, Sara E. Dobbins, Rose Yinghan Behncke, Kazim Ogmen
| The Journal of Clinical Investigation
ResearchClinical ResearchGeneticsVascular biology Open Access | 10.1172/jci.insight.177656 JCI Insight. https://doi.org/10.1172/jci.insight.177656. Copyright © 2025, Ogmen et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Pathogenic variants in kinesin KIF11 underlie microcephaly-lymphedema-chorioretinopathy (MLC) syndrome.
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Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & Evolution

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By Christian Feregrino, Silvia Aldrovandi, Anna A. Monaco, Alessa Ringel, Ariadna Morales, Tobias Zehnder, Rose Yinghan Behncke, Juliane Glaser, Alexander M. Barclay, Guillaume Andrey, Bjørt K. Kragesteen, René Hägerling, Stefan A. Haas, Martin Vingron, Igor Ulitsky, Julio C. Hechavarría, Nicolas Fasel, Michael Hiller, Darío G. Lupiáñez, Stefan Mundlos
| Nature Verified
Abstract Bats are the only mammals capable of self-powered flight, an evolutionary innovation based on the transformation of forelimbs into wings. The bat wing is characterized by an extreme elongation of the second to fifth digits with a wing membrane called the chiropatagium connecting them. Here we investigated the developmental and cellular origin of this structure by comparing bat and mouse limbs using omics tools and single-cell analyses.
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Single-cell, whole-embryo phenotyping of mammalian developmental disorders - Nature

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By Chengxiang Qiu, Oana Amarie, Rose Yinghan Behncke, Diane E. Dickel, Madeleine Duran, Helmut Fuchs, Valerie Gailus-Durner, Sudha Rajderkar, Michael Robson, Lauren Saunders, Yiwen Zhu, Vera M. Kalscheuer, Daniel M. Ibrahim, Ingo Kurth, Axel Visel, Len A. Pennacchio, Cole Trapnell, Junyue Cao, Jay Shendure, Nils Hansmeier, Uwe Kornak
| Nature Verified
Abstract Mouse models are a critical tool for studying human diseases, particularly developmental disorders1. However, conventional approaches for phenotyping may fail to detect subtle defects throughout the developing mouse2. Here we set out to establish single-cell RNA sequencing of the whole embryo as a scalable platform for the systematic phenotyping of mouse genetic models.
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