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Rudolph E. Tanzi

Boston
As seen in: LinkedIn, CNN, Yahoo Life, HuffPost, Nature, The Times of India, Wiley Online Library, NBC News, PLOS ONE, Frontiers and
Neuroscientist; Professor of Neurology, Harvard Med School & MGH; Professional Keyboardist; Best Selling Author: Super Brain, Super Genes & The Healing Self
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Articles

Bacillus Calmette–Guérin (BCG) immunotherapy reprograms CNS immunity and alters Alzheimer’s biomarkers: results from two open-label clinical trials

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By Marc Weinberg Verified, Mahesh Chandra Kodali, Zhaozhi Li, Arianna R. Tidball, William Reynolds, Hadia Fatima, Pia Kivisäkk, Arpita Kulkarni, Alexandra Bartlett, Shannan Ho Sui, Willem M. Kühtreiber, Alison McManus, Rudolph E. Tanzi, Sudeshna Das, Denise L. Faustman, Steven Arnold, Jake A. Galler, Cathrine Young, Kelli Devitte- McKee, Mandovi Chatterjee, James M. Billingsly
| Nature Verified
Abstract Immune aging may contribute to Alzheimer’s disease. Bacillus Calmette–Guérin (BCG), a vaccine known to induce trained immunity, has been linked to reduced Alzheimer’s risk in prior studies. However, whether trained immunity can be observed in the human central nervous system remains unclear. We assessed whether BCG induces trained immunity–like responses in adults with and without Alzheimer’s-related changes.
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Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition

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By Francisco Almeida, Amogh Changavi, Virginia Estades Ayuso, Guadalupe Sánchez, Megan Barber, Patricia Sacilotto, Yuka A. Martens, Michael G. Heckman, Guojun Bu, Rudolph E. Tanzi, Jean-Leon Thomas, John D. Fryer, Tiago Oliveira, Karthik Shekhar, Sandro Da Mesquita, Nickoleta Delivanoglou, Kennedi T. Todd, Shanon Rego, Myriam Spajer, Liliana M. Pinho-Correia, Racquelle Schrader
| Cell Press Verified
Keywords APOE4 sexual dimorphism meninges macrophages lymphatic drainage CSF1R inhibitor brain lipids neuroinflammation cognition human brain leukocytes Introduction Apolipoprotein E (APOE) is the main lipid carrier in the brain. The human APOE gene has three polymorphic alleles, namely APOE2, APOE3 (E3), and APOE4 (E4).
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RIN3 mutations impairing binding of the Alzheimer’s disease-associated protein BIN1 lead to RAB5 hyperactivation and endosomal pathology

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By Jae Yeon Hwang, Jessica King, Ying Hu, Anna Maaser-Hecker, Jacob Zellmer, Michelle Kim, Grisilda Bakiasi, Amit K. Maiti, Dmitry Prokopenko, Rudolph E. Tanzi, Raja Bhattacharyya
| Science Magazine Verified
Abstract Alzheimer’s disease (AD) risk is strongly influenced by genetic variants that converge on pathways regulating endosomal homeostasis. Among these, BIN1 and RIN3 have emerged as susceptibility genes, yet their functional relationship in AD remains largely unknown. Here, we investigated how BIN1 and RIN3 interaction regulates RAB5 activity and endosomal pathology.
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