Alina Marymonchyk on Muck Rack

Alina Marymonchyk

As seen in: Cell Stem Cell
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Articles

Neural stem cell quiescence and activation dynamics are regulated by feedback input from their progeny under homeostatic and regenerative conditions

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By Alina Marymonchyk, Ashleigh Willis, Frédéric Beaupré, Marina Snapyan, Valerie Clavet-Fournier, Flavie Lavoie-Cardinal, DAVID KAPLAN, Freda D. Miller, Armen Saghatelyan, Raquel Rodriguez-Aller, Sareen Warsi
| Cell Stem Cell
Keywords neural stem cells NSCs subventricular zone transient amplifying cells TAPs ephrin signaling spatial transcriptomics CRISPR-Cas9 optogenetics machine learning Get full text access Log in, subscribe or purchase for full access. References 1. Denoth-Lippuner, A. ∙ Jessberger, S. Formation and integration of new neurons in the adult hippocampus Nat. Rev. Neurosci. 2021; 22:223-236 2. Urbán, N. ∙ Cheung, T.H. Stem cell quiescence: the challenging path to activation Development. 2021; 148, dev165084 3.
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Adult neural stem cell activation in mice is regulated by the day/night cycle and intracellular calcium dynamics

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By Archana Gengatharan, Sarah Malvaut, Jovica Ninkovic, Magdalena Götz, Alina Marymonchyk, Majid Ghareghani, Marina Snapyan, Judith Fischer-Sternjak, Armen Saghatelyan
| ScienceDirect
Highlights • Adult neural stem cell (NSC) activation is regulated by the day/night cycle • NSC states differ in Ca2+ dynamics and steady-state levels • Darkness-induced melatonin signaling modulates NSC states via calcium • Mimicking quiescent-state Ca2+ entry reverses switch to NSC proliferative state Summary Neural stem cells (NSCs) in the adult brain transit from the quiescent state to proliferation to produce new neurons.
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