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Keywords Alzheimer's disease AD human astrocytes hAstrocytes human induced pluripotent stem cells hiPSCs chimeric mice apolipoprotein E APOE amyloid-beta Aβ Research topic(s) CP: neuroscience CP: stem cell research Introduction The apolipoprotein E (APOE4) variant of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD).
Highlights • Spatial transcriptomics identifies a plaque-induced gene (PIG) network • Spatial transcriptomics identifies an oligodendrocyte gene (OLIG) response in AD • In situ sequencing in mouse and human confirms these responses at single-cell level • PIG and OLIG responses are conserved over different neurodegenerative diseases Summary Although complex inflammatory-like alterations are observed around the amyloid plaques of Alzheimer’s disease (AD), little is known about the molecular...
Synaptic dysfunction is an early pathological feature of neurodegenerative diseases associated with Tau, including Alzheimer’s disease. Interfering with early synaptic dysfunction may be therapeutically beneficial to prevent cognitive decline and disease progression, but the mechanisms underlying synaptic defects associated with Tau are unclear.
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