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Articles by André Lieber
A neutralizing monoclonal antibody targeting species B adenoviruses largely mimics the DSG2 receptor engagement mechanism
Abstract Species B human adenoviruses (B-HAdVs), including HAdV7, HAdV3, and the re-emerging HAdV55, cause severe respiratory disease and engage desmoglein-2 (DSG2) through their fiber knob. Here, we report the identification and structural characterization of two monoclonal antibodies, 5C5 and 6G7, raised against the HAdV7 fiber knob. Both antibodies neutralize HAdV7 and display cross-reactivity toward other B-HAdVs, with nanomolar affinities.
De novo design of miniproteins targeting GPCRs
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Abstract G protein-coupled receptors (GPCRs) play key roles in physiology and are central targets for drug discovery and development1,2, but the design of protein agonists and antagonists has been challenging as GPCRs are integral membrane proteins and conformationally dynamic3–6. Here we describe computational de novo design methods and a high-throughput “receptor diversion” microscopy-based screen for generating GPCR binding miniproteins with high affinity, potency and selectivity.
By Edin Muratspahić, David Feldman, Xiangli Qu, Paula Rivera-Sánchez, Jan Hendrik Voss, Emil P. T. Hertz, Mads Jeppesen, Federica Dimitri, Kensuke Sakamoto, Amrita Nallathambi, Jianjun Cao, Brian P. Cary, Matthew Belousoff, Peter Keov, Phuc Trinh, Qingchao Chen, Yue Ren, Sudha Mishra, Annu Dalal, Ramanuj Banerjee, Manisankar Ganguly, Isaac Sappington, Thomas Schlichthaerle, Jason Zhang, Arvind Pillai, Brian Coventry, Ljubica Mihaljevic, Magnus Krogstad Bauer, Susana Torres, Amir Motmaen, Gyu Lee, Long Tran, Xinru Wang, Inna Goreshnik, Dionne Vafeados, Justin E. Svendsen, Parisa Hosseinzadeh, Matthäus Brandt, Yann Waltenspühl, Kristine Deibler, Anja Bennett, Jendrik Schöppe, Xiaoli Yan, William Cao, Ayodeji A. Asuni, Justin G. English, Lance Stewart, Lauren Kay Halloran, Jamie B. Spangler, André Lieber, Arun Shukla, Patrick Sexton, Bryan Roth, Brian Krumm, Denise Wootten, Christopher Tate, Christoffer Norn, David Baker, Ana-Maria Bratovianu, Pia Peceli, Justyn Fine, Shachie Sinha, Karthik Varappalayam Karuppusamy, Nicolai Lindegaard, Lukas Deweid, Tiantang Dong, Luke Oostdyk, Lakshmi Anantharaman, Johan J. Weisser, Jesper Frank Bastlund, Christoffer Bundgaard
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Nature
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Role of Fiber Shaft Length in Tumor Targeting with Ad5/3 Vectors
Open AccessArticle by Maximilian Richter , Hongjie Wang and André Lieber * Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA * Author to whom correspondence should be addressed.
Beyond a Global Deal? A UN+ Approach to Climate Governance
Recorded on 25 May 2011 at Old Theatre, Old Building How can we make progress on climate change in the face of gridlock? Global Governance 2020 is a group of young academics, policymakers and business people from China, the United States and Europe. Robert Falkner is senior lecturer in international relations at LSE and a leading expert on global environmental politics. Anthony Giddens is former director of LSE and the author, most recently, of The Politics of Climate Change.
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