Mads Jeppesen

Abstract G protein-coupled receptors (GPCRs) play key roles in physiology and are central targets for drug discovery and development1,2, but the design of protein agonists and antagonists has been challenging as GPCRs are integral membrane proteins and conformationally dynamic3–6. Here we describe computational de novo design methods and a high-throughput “receptor diversion” microscopy-based screen for generating GPCR binding miniproteins with high affinity, potency and selectivity.

Abstract Virus capsid formation is one the most complex self-assembly processes in nature, involving the association of a large number of protein subunits into well-defined structural states. The ability of protein subunits to efficiently self-assembly is encoded in the protein sequence, and ultimately in the protein-protein interfaces within the growing capsid.

Abstract Ice nucleation particles play a crucial role in atmospheric processes e.g., they can trigger ice formation in clouds and thus influence their lifetime and optical properties. The quantification and characterisation of these particles require reliable and precise measurement techniques. In this study, we present a novel droplet freezing instrument to measure immersion freezing of biotic and abiotic ice-nucleating particles within the temperature range of 0°C to -25°C.