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De novo design of miniproteins targeting GPCRs

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By Edin Muratspahić, David Feldman, Xiangli Qu, Paula Rivera-Sánchez, Jan Hendrik Voss, Emil P. T. Hertz, Mads Jeppesen, Federica Dimitri, Kensuke Sakamoto, Amrita Nallathambi, Jianjun Cao, Brian P. Cary, Matthew Belousoff, Peter Keov, Phuc Trinh, Qingchao Chen, Yue Ren, Sudha Mishra, Annu Dalal, Ramanuj Banerjee, Manisankar Ganguly, Isaac Sappington, Thomas Schlichthaerle, Jason Zhang, Arvind Pillai, Brian Coventry, Ljubica Mihaljevic, Magnus Krogstad Bauer, Susana Torres, Amir Motmaen, Gyu Lee, Long Tran, Xinru Wang, Inna Goreshnik, Dionne Vafeados, Justin E. Svendsen, Parisa Hosseinzadeh, Matthäus Brandt, Yann Waltenspühl, Kristine Deibler, Anja Bennett, Jendrik Schöppe, Xiaoli Yan, William Cao, Ayodeji A. Asuni, Justin G. English, Lance Stewart, Lauren Kay Halloran, Jamie B. Spangler, André Lieber, Arun Shukla, Patrick Sexton, Bryan Roth, Brian Krumm, Denise Wootten, Christopher Tate, Christoffer Norn, David Baker, Ana-Maria Bratovianu, Pia Peceli, Justyn Fine, Shachie Sinha, Karthik Varappalayam Karuppusamy, Nicolai Lindegaard, Lukas Deweid, Tiantang Dong, Luke Oostdyk, Lakshmi Anantharaman, Johan J. Weisser, Jesper Frank Bastlund, Christoffer Bundgaard
| Nature Verified
Abstract G protein-coupled receptors (GPCRs) play key roles in physiology and are central targets for drug discovery and development1,2, but the design of protein agonists and antagonists has been challenging as GPCRs are integral membrane proteins and conformationally dynamic3–6. Here we describe computational de novo design methods and a high-throughput “receptor diversion” microscopy-based screen for generating GPCR binding miniproteins with high affinity, potency and selectivity.
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