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Articles by Ann E. Jerse
Copper sulfate–lactic acid combinations exhibit broad-spectrum microbicidal activity against viral and bacterial sexually transmitted pathogens in vitro and in vivo
Abstract Sexually transmitted infections (STIs) and unintended pregnancy remain critical global public health concerns affecting millions of women worldwide. To support the development of new multipurpose products offering non-hormonal contraception and activity against sexually transmitted pathogens, we evaluated copper sulfate, zinc lactate, L-(+)-lactic acid and their combinations as candidate pharmaceutical actives.
A penicillin-binding protein inhibitor series to target drug-resistant Neisseria gonorrhoeae
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Abstract Emerging multidrug-resistant Neisseria gonorrhoeae strains possessing altered penA alleles (encoding penicillin-binding protein 2, PBP2) threaten the utility of ceftriaxone, the last remaining outpatient antibiotic for gonorrhoea treatment, posing a global health emergency. Here we report a benzoxaborinine-based penicillin-binding protein inhibitor series (boro-PBPi) developed to address penA-mediated ceftriaxone resistance.
By Tsuyoshi Uehara, Brittany Miller, Lindsay M. Avery, Steven Boyd, Mitchell Edwards, Susan Hart, Nathan J. Line, Cullen L. Myers, Annie Stevenson, Kyoko Uehara, Fan Yi, Bibo Wang, Zhenwu Liu, Mingyue Wang, Zhichao Zhao, Haiyan Zhao, Caleb Stratton, Christopher Davies, Rok Tkavc, Ann E. Jerse, Christopher Burns, Denis Daigle, Stephen Condon, Allison L. Zulli, Cassandra L. Chatwin, Guo-Hua Chu, Anthony S. Drager, Gopinath Rongala, Xinming Zhou, Sandeepchowdary Bala, Daniel C. Pevear
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Nature
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Gonococcal outer membrane vesicle vaccines: bacterial population biology, clinical trials, immune profiling, and vaccine design - npj Vaccines
Abstract Gonorrhoea is a global health concern exacerbated by rising antimicrobial resistance. Retrospective analyses indicate that outer membrane vesicle (OMV) vaccines derived from Neisseria meningitidis (MeNZB, 4CMenB) may offer partial cross-protection against gonococcal infection.
Irradiated whole cell Chlamydia vaccine confers significant protection in a murine genital tract challenge model - npj Vaccines
Abstract Chlamydia trachomatis infections are the most common bacterial STIs globally and can lead to serious morbidity if untreated. Development of a killed, whole-cell vaccine has been stymied by coincident epitope destruction during inactivation. Here, we present a prototype Chlamydia vaccine composed of elementary bodies (EBs) from the related mouse pathogen, Chlamydia muridarum (Cm).
Profiling IgG and IgA antibody responses during vaccination and infection in a high-risk gonorrhoea population - Nature Communications
Abstract Development of a vaccine against gonorrhoea is a global priority, driven by the rise in antibiotic resistance. Although Neisseria gonorrhoeae (Ng) infection does not induce substantial protective immunity, highly exposed individuals may develop immunity against re-infection with the same strain. Retrospective epidemiological studies have shown that vaccines containing Neisseria meningitidis (Nm) outer membrane vesicles (OMVs) provide a degree of cross-protection against Ng infection.
Gonococcal PorB: a multifaceted modulator of host immune responses
Highlights The essential gonococcal outer-membrane porin, PorB, manipulates the innate immune response via recruitment of negative regulators of the complement system, and by repressing the killing mechanisms of macrophages and neutrophils. Gonococcal PorB in its native folded conformation suppresses the capability of dendritic cells to stimulate proliferation of T cells.
Advancing vaccine development for gonorrhoea and the Global STI Vaccine Roadmap
REVIEW (Open Access) Previous Next Contents Vol 16(5) Sami L. Gottlieb A F , Ann E. Jerse B , Sinead Delany-Moretlwe C , Carolyn Deal D and Birgitte K. Giersing E + Author Affiliations - Author Affiliations A Department of Reproductive Health and Research, World Health Organization, Avenue Appia 20, 1211 Geneva, Switzerland. B Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
In Vitro Susceptibility of Neisseria gonorrhoeae Strains to Mupirocin, an Antibiotic Reformulated for Parenteral Administration in Nanoliposomes
In Vitro Susceptibility of Neisseria gonorrhoeae Strains to Mupirocin, an Antibiotic Reformulated for Parenteral Administration in Nanoliposomes Ahuva Cerna, Kristie L. Connollyb, Ann E. Jerseb and Yechezkel Barenholza aLaboratory of Membrane and Liposome Research, Department of Biochemistry, IMRIC, The Hebrew University, Hadassah Medical School, Jerusalem, Israel bDepartment of Microbiology and Immunology, F.
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