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Articles by Anthony High
IRS4 is a PI3K-activating cancer dependency up-regulated through DNA rearrangements or epigenetic mechanisms in multiple solid tumors
Abstract Cancer therapeutics frequently fail in clinical trials because of poor therapeutic index (efficacy-to-toxicity ratio). We systematically identified targets likely to have a good therapeutic index, revealing insulin receptor substrate 4 (IRS4) as a dependency in IRS4-expressing cancers.
Pan-neurodegeneration proteomics reveals disease subtypes and molecular signatures
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ResourceOnline nowOpen access Affiliations & Notes 1Departments of Structural Biology and Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN, USA 2Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital, Memphis, TN, USA 3Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn Genomics Institute, Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New...
By Him Shrestha, Huan Sun, Jay M. Yarbro, Donggeun Lee, Danting Liu, Erming Wang, Meghan G. McReynolds, Nan Zhang Verified, Boer Xie, Shu Yang, Kaiwen Yu, Suresh Poudel, Yuxin Li, Zuo-Fei Yuan, Dehui Kong, Minghui Wang, Zhen J Wang, Mingming Niu, Hong Wang, Masihuz Zaman, Ju Wang, David Vanderwall, Yu Sun, Zhiping Wu, Ping-Chung Chen, Bing Bai, Anthony High, Júlia Cavaller. Faura, Chunyu Liu, David Bennett, Erik Johnson, Nicholas T. Seyfried, Allan Levey, Vahram Haroutunian, Geidy E. Serrano, Thomas G Beach, Michael DeTure, Takahisa Kanekiyo, Ronald Petersen, Guojun Bu, Pamela McLean, Dennis W. Dickson, Rosa Rademakers, Gang Yu, Xusheng Wang, Bin Zhang, Junmin Peng
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Cell Press
Verified
Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumor
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Keywords Wilms tumor chemotherapy resistance LIN28B ABCB1 N-MYC MYCN kidney development Research topic(s) CP: cancer Introduction Wilms tumor (WT) is the most common pediatric renal malignancy.1 WT is an embryonal tumor with triphasic, mixed histology consisting of blastemal, epithelial, and stromal elements that mirror cell types in the developing kidney.
By Andrew Fleming, Carolyn M Jablonowski, Hongjian Jin, Siwei Zhang, Surbhi Sona, Karissa Jones, Changde Cheng, Beisi Xu, Christopher Morton, Mary A. Woolard, Prahalathan Pichavaram, Daniel B. Gehle, Sivaraman Natarajan, Kiran Kodali, Vishwajeeth Pagala, Anthony High, Yogesh Kumar, Steven J. Burden, Virginia Valentine, Jake Harbour, Daniel Vocelle, Ti-Cheng Chang, John Easton Verified, Scott Olsen, Geoffrey Neale, Emilia M. Pinto, Jerold E. Rehg, Laura J. Janke, Teresa Santiago, Rani E. George, Xiaotu Ma, Gerard P. Zambetti, Andrew Davidoff, Taosheng Chen, Gang Wu, Xiang Chen, Jun Yang, Andrew Murphy, Deidre Daria
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Cell Reports
Verified
Insolubilome profiling defines molecular features that influence protein insolubility with aging
Keywords protein solubility insolubilome proteostasis aging ectopic proteins inter-organ signaling Get full text access Log in, subscribe or purchase for full access. References 1. Schein, C.H. Solubility as a function of protein structure and solvent components Biotechnology (NY). 1990; 8:308-317 2. Qing, R. ∙ Hao, S. ∙ Smorodina, E. ... Protein Design: From the Aspect of Water Solubility and Stability Chem. Rev. 2022; 122:14085-14179 3. Bludau, I. ∙ Aebersold, R.
Targeting glycerophospholipid biosynthesis overcomes chemoresistance driven by SLFN11 loss in Ewing sarcoma - Cell Death & Disease
Abstract Ewing sarcoma (EWS) is a highly aggressive pediatric malignancy characterized by elevated expression of SLFN11, which impairs DNA repair by binding to and functionally inhibiting DNA repair complexes, thereby enhancing susceptibility to genotoxic therapies. However, relapse remains a major clinical challenge and is often accompanied by the emergence of therapeutic resistance linked to reduced SLFN11 expression.
Prodrug florfenicol amine is activated by intrinsic resistance to target Mycobacterium abscessus - Nature Microbiology
Abstract Non-tuberculous mycobacteria are emerging pathogens with high intrinsic drug resistance. Among these, Mycobacterium abscessus is particularly refractory owing to its extensive array of resistance mechanisms. Here we introduce florfenicol amine (FF-NH2), a major metabolite of the antibiotic florfenicol, which acts as a prodrug with narrow-spectrum activity against M. abscessus−chelonae complex species. FF-NH2 leverages intrinsic M.
Midkine attenuates amyloid-β fibril assembly and plaque formation - Nature Structural & Molecular Biology
Abstract Proteomic profiling of Alzheimer disease (AD) brains has identified numerous understudied proteins, including midkine (MDK), that are highly upregulated and correlated with amyloid-β (Aβ) from the early disease stage but their roles in disease progression are not fully understood. Here, we present that MDK attenuates Aβ assembly and influences amyloid formation in the 5xFAD amyloidosis mouse model.
And the Press-Telegram’s 2024 Scary Stories Contest winners for high school are …
First place Untitled By Audrey Mantong, 12th-grade, St. Anthony High “Well, looks like the power’s out,” the theatre director announces to the Redrum High theatre club within the pitch-black of Edicius Theatre. “Figures for a place that costs virtually nothing to rent,” he mutters. Someone snickers, “It’s probably haunted. Calling it now, someone’s mysteriously gonna die.” The kid beside me whispers, “There actually was a murder here — several.
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